CID2440433 [Ligand Id: 5565] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1385076 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Agonist activity at human brain CB1 receptor expressed in U2OS cells assessed as increase in beta arrestin recruitment after 60 mins by fluorescence assay | F | 4.52 | pEC50 | >30000 | nM | EC50 | Bioorg Med Chem (2017) 25: 4355-4367 [PMID:28673732] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Agonist activity at human CB2 receptor expressed in U2OS cells assessed as increase in GFP-tagged beta arrestin recruitment after 75 mins by fluorescence assay | F | 4.52 | pEC50 | >30000 | nM | EC50 | Bioorg Med Chem (2017) 25: 4355-4367 [PMID:28673732] |
| GPR55/G-protein coupled receptor 55 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6] | ||||||||
| ChEMBL | Agonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assay | B | 6.59 | pEC50 | 260 | nM | EC50 | Bioorg Med Chem (2017) 25: 4355-4367 [PMID:28673732] |
| GtoPdb | - | - | 6.6 | pEC50 | 250 | nM | EC50 | Biochemistry (2011) 50: 5633-47 [PMID:21534610] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
