MK 6892 [Ligand Id: 5788] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1086657 (MK-6892) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
| ChEMBL | Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albumin | B | 6.23 | pKi | 595 | nM | Ki | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| ChEMBL | Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| GtoPdb | - | - | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2010) 53: 2666-70 [PMID:20184326] |
| ChEMBL | Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay | F | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| GtoPdb | - | - | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2010) 53: 2666-70 [PMID:20184326] |
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4420] [GtoPdb: 312] [UniProtKB: Q9EP66] | ||||||||
| ChEMBL | Agonist activity at mouse GPR109A receptor by [35S]GTPgammaS binding assay | F | 6.62 | pEC50 | 240 | nM | EC50 | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
| HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4731] [GtoPdb: 312] [UniProtKB: Q80Z39] | ||||||||
| ChEMBL | Agonist activity at rat GPR109A receptor by [35S]GTPgammaS binding assay | F | 5.34 | pEC50 | 4600 | nM | EC50 | J Med Chem (2010) 53: 2666-2670 [PMID:20184326] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
