L-692,429 [Ligand Id: 5868] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL308716 (L-692429) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] | ||||||||
| ChEMBL | Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand | B | 7.2 | pKi | 63 | nM | Ki | J Med Chem (1996) 39: 1767-1770 [PMID:8627599] |
| ChEMBL | Inhibition against human growth hormone secretagogue (GHS) receptor | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
| GtoPdb | - | - | 7 | pEC50 | 100 | nM | EC50 | Mol Endocrinol (2005) 19: 2400-11 [PMID:15905359] |
| GtoPdb | - | - | 7.59 | pEC50 | 26 | nM | EC50 | Mol Endocrinol (2005) 19: 2400-11 [PMID:15905359] |
| Ghrelin receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2224] [UniProtKB: Q95254] | ||||||||
| ChEMBL | Inhibition against pig growth hormone secretagogue (GHS) receptor | B | 7.2 | pIC50 | 63 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
| ghrelin receptor/Ghrelin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3278] [GtoPdb: 246] [UniProtKB: O08725] | ||||||||
| ChEMBL | Inhibition against rat growth hormone secretagogue (GHS) receptor | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
| GtoPdb | - | - | 7.22 | pEC50 | 60 | nM | EC50 | Science (1993) 260: 1640-3 [PMID:8503009] |
| ChEMBL | In vitro growth hormone release was determined in rat pituitary cell assay | F | 7.22 | pEC50 | 60 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 107-112 [PMID:9925440] |
| GHRH receptor/Growth hormone-releasing hormone receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709] [GtoPdb: 247] [UniProtKB: Q02644] | ||||||||
| ChEMBL | Ability to release growth hormone in a rat pituitary cell assay | F | 7.22 | pEC50 | 60 | nM | EC50 | Bioorg Med Chem Lett (1997) 7: 2319-2324 |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| ChEMBL | Inhibition against human angiotensin II receptor, type 1 (AG2-R) | B | 5.44 | pIC50 | 3600 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
