compound 56 [PMID: 8568816] [Ligand Id: 5956] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL35820 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fructose-1,6-bisphosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3975] [UniProtKB: P09467] | ||||||||
| ChEMBL | Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 17-21 [PMID:11140724] |
| Fructose-1,6-bisphosphatase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2263] [UniProtKB: P00636] | ||||||||
| ChEMBL | Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 17-21 [PMID:11140724] |
| Fructose-1,6-bisphosphatase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4391] [UniProtKB: P19112] | ||||||||
| ChEMBL | Compound was evaluated for its concentration required to inhibit the rat liver F16BPase | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 17-21 [PMID:11140724] |
| epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| GtoPdb | - | - | 11.22 | pIC50 | 0.01 | nM | IC50 | J Med Chem (1996) 39: 267-76 [PMID:8568816] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
