GSK-3 inhibitor X [Ligand Id: 5975] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL430226 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aryl hydrocarbon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3201] [GtoPdb: 2951] [UniProtKB: P35869] | ||||||||
| ChEMBL | Agonist activity at human aryl hydrocarbon receptor | F | 6.8 | pEC50 | 160 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibitory activity against cyclin dependent kinase 1-cyclinB from starfish (Marthasterias glacialis) oocytes | B | 4.2 | pIC50 | 63000 | nM | IC50 | J Med Chem (2004) 47: 935-946 [PMID:14761195] |
| ChEMBL | Inhibition of CDK1/cyclinB | B | 4.2 | pIC50 | 63000 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2004) 47: 935-946 [PMID:14761195] |
| glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029] | ||||||||
| GtoPdb | Measured using GSK3 as a complex of α and β isozymes, isolated from pig brain | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2004) 47: 935-46 [PMID:14761195] |
| glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030] | ||||||||
| GtoPdb | Measured using GSK3 as a complex of α and β isozymes, isolated from pig brain | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2004) 47: 935-46 [PMID:14761195] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
