ChEMBL ligand: CHEMBL596674
Protein-glutamine gamma-glutamyltransferase in Guinea pig [ChEMBL: CHEMBL3308976] [UniProtKB: Q7M0F8] There should be some charts here, you may need to enable JavaScript!
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458] There should be some charts here, you may need to enable JavaScript!
transglutaminase 2 in Human [GtoPdb: 3015] [UniProtKB: P21980] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Protein-glutamine gamma-glutamyltransferase in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308976] [UniProtKB: Q7M0F8]
ChEMBL	Inhibition of guinea pig liver transglutaminase	B	5.4	pIC50	4000	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1141-1144 [PMID:20053561]
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7]
ChEMBL	MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate	F	5.09	pIC50	8100	nM	IC50	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate	F	6.24	pIC50	580	nM	IC50	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL	Inhibition of JAK3 (unknown origin) by ELISA	B	7.1	pIC50	80	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4229-4237 [PMID:28844493]
GtoPdb	-	-	7.1	pIC50	79	nM	IC50	Bioorg Med Chem Lett (2000) 10: 575-9 [PMID:10741557]
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb	-	-	4.4	pIC50	39810	nM	IC50	Bioorg Med Chem Lett (2000) 10: 575-9 [PMID:10741557]
transglutaminase 2 in Human [GtoPdb: 3015] [UniProtKB: P21980]
GtoPdb	In the absence of DTT.	-	8	pIC50	10	nM	IC50	Chem Biol (2008) 15: 969-78 [PMID:18804034]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]