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ChEMBL ligand: CHEMBL313417 (SK-86002, SK&F-86002) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
ChEMBL | Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (1996) 39: 3929-3937 [PMID:8831759] |
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
ChEMBL | Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle | B | 5.27 | pIC50 | 5400 | nM | IC50 | J Med Chem (1996) 39: 3929-3937 [PMID:8831759] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-pyrazol-1-yl)phenylamino)acetamide) from inactive form of p38alpha expressed in Escherichia coli BL21(DE3) cells by enzyme fragment complementation assay | B | 6.09 | pIC50 | 820 | nM | IC50 | J Med Chem (2010) 53: 357-367 [PMID:19928858] |
ChEMBL | In vitro inhibitory concentration against Mitogen-activated protein kinase p38 alpha | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2003) 46: 4702-4713 [PMID:14561090] |
ChEMBL | Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assay | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2010) 53: 357-367 [PMID:19928858] |
GtoPdb | Measured using a classic homogeneous time-resolved fluorescence (HTRF) kinase assay | - | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2010) 53: 357-67 [PMID:19928858] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]