oleocanthal [Ligand Id: 6308] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2172394 ((-)-Oleocanthal)
  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • TRPA1 in Human [GtoPdb: 485] [UniProtKB: O75762]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of c-MET phosphorylation (unknown origin) after 1 hr by Z'-LYTE kinase assay B 5.26 pIC50 5500 nM IC50 Bioorg Med Chem (2013) 21: 2117-2127 [PMID:23403296]
ChEMBL Inhibition of recombinant human His-tagged c-MET expressed in baculovirus expression system assessed as reduction in c-MET phosphorylation using Tyr6 as substrate incubated for 1 hr by Z'-lyte assay B 5.32 pIC50 4800 nM IC50 Bioorg Med Chem (2016) 24: 113-122 [PMID:26692349]
TRPA1 in Human [GtoPdb: 485] [UniProtKB: O75762]
GtoPdb Patch clamp - 5.6 pEC50 - - - J Neurosci (2011) 31: 999-1009 [PMID:21248124]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]