enalaprilat [Ligand Id: 6332] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL577 (Enalaprilat, MK-421, MK-422, Vasotec) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (1985) 28: 1291-1295 [PMID:2993618] |
| GtoPdb | - | - | 7.5 | pIC50 | 34 | nM | IC50 | J Cardiovasc Pharmacol (1994) 23 Suppl 4: S11-5 [PMID:7527095] |
| ChEMBL | Inhibition of angiotensin I converting enzyme in silico | B | 8.4 | pIC50 | 3.98 | nM | IC50 | J Med Chem (1997) 40: 3161-3172 [PMID:9379435] |
| ChEMBL | Compound was tested for its inhibitory potency against angiotensin I converting enzyme. | B | 8.51 | pIC50 | 3.1 | nM | IC50 | J Med Chem (1991) 34: 511-517 [PMID:1995872] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme from pig renal cortex, hippuryl-histidyl-leucine as substrate | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (1989) 32: 289-297 [PMID:2913292] |
| ChEMBL | Compound tested in vitro for inhibition of Angiotensin I converting enzyme | B | 8.59 | pIC50 | 2.6 | nM | IC50 | J Med Chem (1989) 32: 1600-1606 [PMID:2544729] |
| ChEMBL | Inhibition of human plasma ACE | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2313-2318 [PMID:28442252] |
| ChEMBL | Inhibition of guinea pig angiotensin I converting enzyme | B | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (1986) 29: 1953-1961 [PMID:3020249] |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in Hog plasma | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1985) 28: 434-442 [PMID:2984419] |
| ChEMBL | Inhibitory concentration against Angiotensin I converting enzyme | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1986) 29: 251-260 [PMID:3005569] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1993) 36: 2051-2058 [PMID:8340909] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2002) 45: 5609-5616 [PMID:12477342] |
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | Inhibitory activity against rabbit lung angiotensin-1 converting enzyme | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (1988) 31: 1148-1160 [PMID:2836590] |
| ChEMBL | Evaluation of in vitro inhibitory activity against Angiotensin I converting enzyme | B | 8.06 | pIC50 | 8.8 | nM | IC50 | J Med Chem (1995) 38: 5023-5030 [PMID:8544178] |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in rabbit lung | B | 8.24 | pIC50 | 5.8 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | Inhibitory activity against rabbit lung Angiotensin I converting enzyme with 5 mM hippuryl-histidyl-leucine as substrate | B | 8.24 | pIC50 | 5.7 | nM | IC50 | J Med Chem (1987) 30: 1984-1991 [PMID:3669006] |
| ChEMBL | Concentration required for 50% inhibition of rabbit lung Angiotensin I converting enzyme with 5 mM hippuryl-histidyl-leucine as substrate | B | 8.24 | pIC50 | 5.7 | nM | IC50 | J Med Chem (1988) 31: 422-428 [PMID:3339612] |
| ChEMBL | In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrate | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (1988) 31: 204-212 [PMID:3336020] |
| ChEMBL | In vitro activity against angiotensin I converting enzyme especially against Hip-His-Leu residues | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1991) 34: 663-669 [PMID:1995891] |
| Angiotensin-converting enzyme in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2994] [GtoPdb: 1613] [UniProtKB: P09470] | ||||||||
| ChEMBL | Inhibition of ob/ob mouse plasma ACE | B | 7.94 | pIC50 | 11.5 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2313-2318 [PMID:28442252] |
| Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
| ChEMBL | Inhibition of Wistar rat plasma ACE | B | 8.02 | pIC50 | 9.6 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2313-2318 [PMID:28442252] |
| ChEMBL | In vitro inhibitory activity against angiotensin I converting enzyme of rats. | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (1988) 31: 1148-1160 [PMID:2836590] |
| ChEMBL | Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. | B | 8.64 | pIC50 | 2.3 | nM | IC50 | J Med Chem (1987) 30: 992-998 [PMID:3035180] |
| ChEMBL | Compound was tested for inhibitory activity against angiotensin I converting enzyme | B | 9.02 | pIC50 | 0.95 | nM | IC50 | J Med Chem (1991) 34: 439-447 [PMID:1992145] |
| Angiotensin-converting enzyme 2/Angiotensin-converting enzyme-related carboxypeptidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311] [GtoPdb: 1614] [UniProtKB: Q5EGZ1] | ||||||||
| ChEMBL | Binding affinity towards Angiotensin I converting enzyme of rat brain IgG immobilized enzyme. | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (1985) 28: 1208-1216 [PMID:2993614] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Inhibition of human plasma DPP4 | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 2313-2318 [PMID:28442252] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
