emricasan [Ligand Id: 6508] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL197672 (Emricasan, IDN 6556, IDN-6556, PF 03491390, PF-03491390, VAY-785, VAY785)
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  • Caspase 8 in Human [GtoPdb: 1624] [UniProtKB: Q14790]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574]
ChEMBL Inhibition of Anti-Fas antibody-induced caspase-3 activity in human Jurkat E6-1 cells using Ac-DEVD-AMC substrate by fluorescence based assay B 8.22 pIC50 6 nM IC50 Bioorg Med Chem Lett (2018) 28: 1874-1878 [PMID:29650287]
Caspase 8 in Human [GtoPdb: 1624] [UniProtKB: Q14790]
GtoPdb - - 8.3 pKi 5 nM Ki J Med Chem (2005) 48: 6779-82 [PMID:16250635]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]