UK-356618 [Ligand Id: 6528] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL117225 (UK-356618) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| bone morphogenetic protein 1/Bone morphogenetic protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3898] [GtoPdb: 2333] [UniProtKB: P13497] | ||||||||
| ChEMBL | Inhibitory activity against Procollagen C-terminal proteinase (PCP) | B | 4.28 | pIC50 | 52000 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-1 | B | 4.29 | pIC50 | 51000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human Matrix metalloprotease-1 (MMP-1) | B | 4.29 | pIC50 | 51000 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP1 | B | 4.29 | pIC50 | 51000 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-13 | B | 7.14 | pIC50 | 73 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of Matrix metalloprotease-13 | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP13 | B | 7.14 | pIC50 | 73 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-14 | B | 5.72 | pIC50 | 1900 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of Matrix metalloprotease-14 | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP14 | B | 5.72 | pIC50 | 1900 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Concentration required to inhibit the catalytic domain Matrix metalloprotease-2 using Nagase fluorogenic as a substrate. | B | 5.75 | pIC50 | 1790 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human matrix metalloprotease-2 (MMP-2) | B | 5.75 | pIC50 | 1790 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP2 | B | 5.75 | pIC50 | 1790 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| GtoPdb | - | - | 8.2 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-4 [PMID:11229774] |
| ChEMBL | Concentration required to inhibit the catalytic domain Matrix metalloprotease-3 using Nagase fluorogenic as a substrate. | B | 8.23 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human matrix metalloprotease-3 (MMP-3) | B | 8.23 | pIC50 | 5.9 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP3 | B | 8.23 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP3 | B | 8.23 | pIC50 | 5.89 | nM | IC50 | Bioorg Med Chem (2007) 15: 2223-2268 [PMID:17275314] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-9 | B | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 571-574 [PMID:11229774] |
| ChEMBL | Inhibition of human matrix metalloprotease-9 (MMP-9) | B | 6.08 | pIC50 | 840 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
| ChEMBL | Inhibition of MMP9 | B | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
