S 17092 [Ligand Id: 6565] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1086968 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | 1.5 | nM | Ki | J Med Chem (2010) 53: 3423-38 [PMID:20058865] |
| ChEMBL | Inhibition of human POP | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2010) 53: 3423-3438 [PMID:20058865] |
| ChEMBL | Inhibition of human POP using Z-Gly-Pro-7-AMC substrate | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2016) 59: 4221-4234 [PMID:26619267] |
| ChEMBL | Inhibition of human recombinant POP expressed in sEscherichia coli | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4360-4363 [PMID:18606544] |
| prolyl endopeptidase/Prolyl endopeptidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4035] [GtoPdb: 2395] [UniProtKB: O70196] | ||||||||
| ChEMBL | inhibition of rat cortex POP | B | 8.89 | pKi | 1.3 | nM | Ki | J Med Chem (2010) 53: 3423-3438 [PMID:20058865] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
