compound 3 [PMID: 9003518] [Ligand Id: 6720] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL64905 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
| ChEMBL | Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicans | B | 9.66 | pIC50 | 0.22 | nM | IC50 | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
| lanosterol synthase/Lanosterol synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
| ChEMBL | Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liver | B | 5.82 | pKi | 1500 | nM | Ki | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
| ChEMBL | Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liver | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
| ChEMBL | Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from pig liver | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
| GtoPdb | - | - | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1997) 40: 201-9 [PMID:9003518] |
| ChEMBL | Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liver | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1997) 40: 201-209 [PMID:9003518] |
| ChEMBL | Inhibition of rat OSC | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem (2007) 15: 4674-4699 [PMID:17521912] |
| Lanosterol synthase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075056] [UniProtKB: Q04782] | ||||||||
| ChEMBL | Inhibition of Candida albicans OSC | B | 9.66 | pIC50 | 0.22 | nM | IC50 | Bioorg Med Chem (2007) 15: 4674-4699 [PMID:17521912] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
