ChEMBL ligand: CHEMBL866 (68618, Mycophenolate, Mycophenolate mofetil impurity, mycophenolic acid-, Mycophenolic acid, Myfortic, NSC-129185, RS-61443 [AS MOFETIL])
Inosine-5`-monophosphate dehydrogenase in Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /ATCC MYA-565) (Filobasidiella neoformans) [ChEMBL: CHEMBL4295605] [UniProtKB: Q5KP44] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Inosine-5`-monophosphate dehydrogenase in Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /ATCC MYA-565) (Filobasidiella neoformans) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295605] [UniProtKB: Q5KP44]
ChEMBL	Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839]
ChEMBL	Inhibition of human IMPDH 1	B	7.4	pKi	40	nM	Ki	J Med Chem (2007) 50: 6685-6691 [PMID:18038969]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)	B	7.4	pKi	40	nM	Ki	J Med Chem (2002) 45: 703-712 [PMID:11806722]
ChEMBL	Inhibition of human IMPDH1	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem (2008) 16: 9340-9345 [PMID:18809333]
ChEMBL	Inhibition of human IMP dehydrogenase 1	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I isoform); Range is 33-37 nM	B	7.48	pKi	33	nM	Ki	J Med Chem (1998) 41: 618-622 [PMID:9484510]
ChEMBL	Inhibition of human IMPDH type 1	B	7.48	pKi	33	nM	Ki	J Med Chem (2007) 50: 5743-5751 [PMID:17958343]
ChEMBL	Inhibition of human IMPDH1 by Spectrophotometry	B	7.48	pKi	33	nM	Ki	Bioorg Med Chem (2011) 19: 1594-1605 [PMID:21324702]
ChEMBL	Inhibition of recombinant human His-tagged IMPDH1 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
ChEMBL	Inhibitory activity against inosine monophosphate dehydrogenase IMPDH type I	B	7.26	pIC50	55	nM	IC50	Bioorg Med Chem Lett (2003) 13: 543-546 [PMID:12565968]
ChEMBL	Inhibition of human IMPDH1	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3479-3483 [PMID:16621550]
ChEMBL	In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase	B	7.7	pIC50	20	nM	IC50	J Med Chem (1990) 33: 833-838 [PMID:1967654]
GtoPdb	Reference does not distinguish which enzyme isoform is assayed	-	7.7	pIC50	20	nM	IC50	J Med Chem (1990) 33: 833-8 [PMID:1967654]
ChEMBL	Inhibition of human IMPDH1 expressed in Escherichia coli strain BL21(DE3) after 60 mins	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem (2010) 18: 8106-8111 [PMID:20934342]
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268]
ChEMBL	Inhibition of human IMPDH 2	B	8	pKi	10	nM	Ki	J Med Chem (2007) 50: 6685-6691 [PMID:18038969]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)	B	8	pKi	10	nM	Ki	J Med Chem (2002) 45: 703-712 [PMID:11806722]
ChEMBL	Inhibition of human IMPDH2	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2008) 16: 9340-9345 [PMID:18809333]
ChEMBL	Inhibition of human IMP dehydrogenase 2	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139]
ChEMBL	Inhibition of human IMPDH type 2	B	8.15	pKi	7	nM	Ki	J Med Chem (2007) 50: 5743-5751 [PMID:17958343]
ChEMBL	Inhibition of human IMPDH2 by Spectrophotometer	B	8.15	pKi	7	nM	Ki	Bioorg Med Chem (2011) 19: 1594-1605 [PMID:21324702]
ChEMBL	Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nM	B	8.22	pKi	6	nM	Ki	J Med Chem (1998) 41: 618-622 [PMID:9484510]
ChEMBL	Inhibition of IMPDH2	B	5.82	pIC50	1500	nM	IC50	Bioorg Med Chem Lett (2012) 22: 53-56 [PMID:22172700]
ChEMBL	Inhibition of IMPDH2 using inosine 5'-monophosphate as substrate by spectrophotometry	B	6.2	pIC50	630	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3332-3335 [PMID:22464133]
ChEMBL	Inhibition of human IMPDH2 using IMP as substrate in presence of NAD+ after 30 mins	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2018) 158: 286-301 [PMID:30223117]
ChEMBL	Inhibition of recombinant human His-tagged IMPDH2 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754]
ChEMBL	Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 7.4	B	7.6	pIC50	25.1	nM	IC50	J Med Chem (1996) 39: 4181-4196 [PMID:8863796]
ChEMBL	Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 8.0	B	7.61	pIC50	24.8	nM	IC50	J Med Chem (1996) 39: 4181-4196 [PMID:8863796]
GtoPdb	Reference does not distinguish which enzyme isoform is assayed	-	7.7	pIC50	20	nM	IC50	J Med Chem (1990) 33: 833-8 [PMID:1967654]
ChEMBL	Inhibition of human IMPDH2	B	7.8	pIC50	16	nM	IC50	J Med Chem (2007) 50: 3730-3742 [PMID:17585753]
ChEMBL	In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2931-2934 [PMID:12270177]
ChEMBL	Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II)	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3125-3128 [PMID:12372516]
ChEMBL	Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3557-3560 [PMID:14505670]
ChEMBL	Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3305-3308 [PMID:12392738]
ChEMBL	Inhibition of human Inosine-5'-monophosphate dehydrogenase 2	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2137-2140 [PMID:12127522]
ChEMBL	Inhibition of human inosine monophosphate dehydrogenase IMPDH II	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2003) 13: 543-546 [PMID:12565968]
ChEMBL	Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2003) 13: 547-551 [PMID:12565969]
ChEMBL	Inhibition of human inosine-5'-monophosphate dehydrogenase 2	B	7.85	pIC50	14	nM	IC50	J Med Chem (2002) 45: 2127-2130 [PMID:12014950]
ChEMBL	Inhibition of human IMPDH2 expressed in Escherichia coli strain BL21(DE3) after 60 mins	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem (2010) 18: 8106-8111 [PMID:20934342]
ChEMBL	Inhibition of human IMPDH2	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3479-3483 [PMID:16621550]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells	F	6	pIC50	1000	nM	IC50	Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection	F	5.3	pIC50	>5000	nM	IC50	Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]