NQN-1 [Ligand Id: 7058] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1717890 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| GtoPdb | - | - | 5.89 | pKi | 1300 | nM | Ki | ACS Chem Biol (2012) 7: 331-9 [PMID:22047054] |
| ChEMBL | Inhibition of human recombinant HDAC6 using Ac-Leu-Gly-(AMC)Lys-Ac as substrate | B | 5.26 | pIC50 | 5540 | nM | IC50 | J Med Chem (2013) 56: 6297-6313 [PMID:23627282] |
| ChEMBL | Inhibition of recombinant human HDAC6 expressed in baculovirus expression system using AMC-K(Ac)GL as substrate by fluorescence method | B | 5.26 | pIC50 | 5540 | nM | IC50 | Eur J Med Chem (2018) 143: 1406-1418 [PMID:29133060] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
