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ChEMBL ligand: CHEMBL7492 (Bw 301u, Bw-301u, BW-301U, Piritrexim, TCMDC-137235) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Bacterial dihydrofolate reductase in Bacteria (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2364669] [UniProtKB: P0ABQ4] | ||||||||
ChEMBL | In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (2002) 45: 233-241 [PMID:11754594] |
Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4] | ||||||||
ChEMBL | Inhibition of dihydrofolate reductase in pneumocystis carinii. | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1993) 36: 3103-3112 [PMID:8230096] |
ChEMBL | Inhibition of dihydrofolate reductase from pneumocystis carinii. | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (2003) 46: 5074-5082 [PMID:14584957] |
ChEMBL | Inhibition of dihydrofolate reductase in Toxoplasma gondii. | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1993) 36: 3103-3112 [PMID:8230096] |
ChEMBL | Inhibition of dihydrofolate reductase from Toxoplasma gondii. | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2003) 46: 5074-5082 [PMID:14584957] |
Dihydrofolate reductase in Lactobacillus casei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2902] [UniProtKB: P00381] | ||||||||
ChEMBL | Inhibitory activity against dihydrofolate reductase in mammalians. (high potency) | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
Dihydrofolate reductase in Mycobacterium avium (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5457] [UniProtKB: O30463] | ||||||||
ChEMBL | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | B | 9.21 | pIC50 | 0.61 | nM | IC50 | J Med Chem (2004) 47: 1475-1486 [PMID:14998335] |
ChEMBL | Inhibitory concentration against Mycobacterium avium dihydrofolate reductase | B | 9.21 | pIC50 | 0.61 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078] |
ChEMBL | Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range: 0.53-0.70 | B | 9.21 | pIC50 | 0.61 | nM | IC50 | J Med Chem (2004) 47: 2475-2485 [PMID:15115391] |
ChEMBL | Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium | B | 9.21 | pIC50 | 0.61 | nM | IC50 | J Med Chem (2003) 46: 1726-1736 [PMID:12699390] |
ChEMBL | Inhibitory concentration against Mycobacterium avium DHFR | B | 9.21 | pIC50 | 0.61 | nM | IC50 | J Med Chem (2005) 48: 4420-4431 [PMID:15974594] |
Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184] | ||||||||
ChEMBL | Binding affinity was reported with purified recombinant Pneumocystis carinii Dihydrofolate reductase | B | 9.84 | pKi | 0.14 | nM | Ki | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
ChEMBL | Inhibitory concentration against Dihydrofolate reductase from Pneumocystis carinii (pc) | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1997) 40: 470-478 [PMID:9046337] |
ChEMBL | Inhibition of Pneumocystis carinii (pc) Dihydrofolate reductase | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1995) 38: 2158-2165 [PMID:7783147] |
ChEMBL | Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii(pc) | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1999) 42: 2447-2455 [PMID:10395486] |
ChEMBL | Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1995) 38: 1778-1785 [PMID:7752201] |
ChEMBL | Inhibition against Dihydrofolate reductase in Pneumocystis carinii | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1997) 40: 1173-1177 [PMID:9089339] |
ChEMBL | Inhibition of Pneumocystis carinii dihydrofolate reductase | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1993) 36: 3437-3443 [PMID:8230134] |
ChEMBL | Inhibition of Dihydrofolate Reductase of Pneumocystis carinii. | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (1997) 40: 479-485 [PMID:9046338] |
ChEMBL | Inhibition of Pneumocystis carinii dihydrofolate reductase | B | 7.46 | pIC50 | 34.3 | nM | IC50 | J Med Chem (2008) 51: 6195-6200 [PMID:18771252] |
ChEMBL | Inhibitory concentration against dihydrofolate reductase dihydrofolate reductase from Pneumocystis carinii. | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (2001) 44: 2391-2402 [PMID:11448221] |
ChEMBL | Inhibition of Pneumocystis carinii dihydrofolate reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1997) 40: 3032-3039 [PMID:9301665] |
ChEMBL | Inhibition of Pneumocystis carinii dihydrofolate reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1997) 40: 3032-3039 [PMID:9301665] |
ChEMBL | Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii. (high potency) | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
ChEMBL | Compound was tested for inhibition activity against pneumocystis carinii (Pneumocystis carinii) Dihydrofolate reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1998) 41: 913-918 [PMID:9526565] |
ChEMBL | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1996) 39: 1271-1280 [PMID:8632434] |
ChEMBL | Inhibitory activity against Pneumocystis carinii Dihydrofolate reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1995) 38: 745-752 [PMID:7877140] |
ChEMBL | Inhibitory concentration against Pneumocystis carinii Dihydrofolate reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1997) 40: 1930-1936 [PMID:9191971] |
ChEMBL | The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was tested | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1999) 42: 1007-1017 [PMID:10090784] |
ChEMBL | Concentration inhibiting Pneumocystis carinii dihydrofolate reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1995) 38: 2615-2620 [PMID:7629801] |
ChEMBL | Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 uM dihydrofolic acid as substrate | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1997) 40: 3040-3048 [PMID:9301666] |
ChEMBL | Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis carinii | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1998) 41: 4533-4541 [PMID:9804692] |
ChEMBL | Inhibition of Dihydrofolate reductase of Pneumocystis carinii | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1994) 37: 4522-4528 [PMID:7799402] |
ChEMBL | Inhibitory activity against Pneumocystis. carinii DHFR* | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (2003) 46: 1726-1736 [PMID:12699390] |
ChEMBL | Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii at 37 centigrade. | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
ChEMBL | Inhibition of Pneumocystis carinii DHFR by spectrophotometric assay | B | 7.72 | pIC50 | 19 | nM | IC50 | Eur J Med Chem (2015) 95: 76-95 [PMID:25794791] |
ChEMBL | Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis carinii | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2003) 46: 1726-1736 [PMID:12699390] |
ChEMBL | Inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | B | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078] |
ChEMBL | Inhibitory concentration against Pneumocystis carinii DHFR | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2005) 48: 4420-4431 [PMID:15974594] |
ChEMBL | Inhibitory concentration against dihydrofolate reductace enzyme of Pneumocystis carinii | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2004) 47: 1475-1486 [PMID:14998335] |
ChEMBL | Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range: 9.0-17 | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2004) 47: 2475-2485 [PMID:15115391] |
ChEMBL | Inhibition of Pneumocystis carinii DHFR | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2013) 56: 4422-4441 [PMID:23627352] |
Dihydrofolate reductase in Candida albicans (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2329] [UniProtKB: P22906] | ||||||||
ChEMBL | Inhibition of Dihydrofolate reductase enzyme from Candida albicans | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1996) 39: 892-903 [PMID:8632413] |
ChEMBL | Inhibition of dihydrofolate reductase in Candida albicans (in vitro). | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (1995) 38: 3608-3616 [PMID:7658448] |
Dihydrofolate reductase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2425] [UniProtKB: Q07422] | ||||||||
ChEMBL | Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2003) 46: 1726-1736 [PMID:12699390] |
ChEMBL | Inhibition of Toxoplasma gondii dihydrofolate reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1997) 40: 3032-3039 [PMID:9301665] |
ChEMBL | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | B | 7.77 | pIC50 | 17 | nM | IC50 | Eur J Med Chem (2015) 95: 76-95 [PMID:25794791] |
ChEMBL | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1996) 39: 1271-1280 [PMID:8632434] |
ChEMBL | Inhibitory activity against Toxoplasma gondii Dihydrofolate reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1995) 38: 745-752 [PMID:7877140] |
ChEMBL | Inhibitory concentration against Toxoplasma gondii Dihydrofolate reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1997) 40: 1930-1936 [PMID:9191971] |
ChEMBL | The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was tested | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1999) 42: 1007-1017 [PMID:10090784] |
ChEMBL | Concentration inhibiting Toxoplasma gondii dihydrofolate reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1995) 38: 2615-2620 [PMID:7629801] |
ChEMBL | Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 uM dihydrofolic acid as substrate | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1997) 40: 3040-3048 [PMID:9301666] |
ChEMBL | Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondii | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1998) 41: 4533-4541 [PMID:9804692] |
ChEMBL | Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg) | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2002) 45: 233-241 [PMID:11754594] |
ChEMBL | Inhibition of Dihydrofolate reductase of Toxoplasma gondii | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1994) 37: 4522-4528 [PMID:7799402] |
ChEMBL | Inhibitory activity against Toxoplasma gondii DHFR* | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2003) 46: 1726-1736 [PMID:12699390] |
ChEMBL | Inhibition of Toxoplasma gondii dihydrofolate reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1997) 40: 3032-3039 [PMID:9301665] |
ChEMBL | Compound was tested for inhibition activity against Toxoplasma gondii (Toxoplasma gondii) Dihydrofolate reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1998) 41: 913-918 [PMID:9526565] |
ChEMBL | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1996) 39: 1836-1845 [PMID:8627607] |
ChEMBL | Inhibitory concentration against dihydrofolate reductase DHFR from Toxoplasma gondii | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2001) 44: 2391-2402 [PMID:11448221] |
ChEMBL | Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1995) 38: 1778-1785 [PMID:7752201] |
ChEMBL | Inhibition of Toxoplasma gondii dihydrofolate reductase | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1993) 36: 3437-3443 [PMID:8230134] |
ChEMBL | Inhibition of Dihydrofolate Reductase of Toxoplasma gondii. | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1997) 40: 479-485 [PMID:9046338] |
ChEMBL | Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (tg) | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1997) 40: 470-478 [PMID:9046337] |
ChEMBL | Inhibition of dihydrofolate reductase (DHFR) from Toxoplasma gondii(tg) | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1999) 42: 2447-2455 [PMID:10395486] |
ChEMBL | Inhibition of Toxoplasma gondii (tc) Dihydrofolate reductase | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1995) 38: 2158-2165 [PMID:7783147] |
ChEMBL | Inhibition against Dihydrofolate reductase in Toxoplasma gondii | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1997) 40: 1173-1177 [PMID:9089339] |
ChEMBL | Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range: 4.0-4.6 | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2004) 47: 2475-2485 [PMID:15115391] |
ChEMBL | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2004) 47: 1475-1486 [PMID:14998335] |
ChEMBL | Inhibitory concentration against Toxoplasma gondii dihydrofolate reductase | B | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078] |
ChEMBL | Inhibitory concentration against Toxoplasma gondii DHFR | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2005) 48: 4420-4431 [PMID:15974594] |
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374] | ||||||||
ChEMBL | Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductase | B | 7.42 | pKi | 38 | nM | Ki | J Med Chem (1995) 38: 745-752 [PMID:7877140] |
ChEMBL | Inhibitory activity against Wild-type human DHFR | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (1995) 38: 745-752 [PMID:7877140] |
ChEMBL | Inhibition of human recombinant Dihydrofolate reductase enzyme | B | 10.6 | pKi | 0.03 | nM | Ki | J Med Chem (1996) 39: 892-903 [PMID:8632413] |
ChEMBL | Inhibition of human recombinant DHFR | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2013) 56: 4422-4441 [PMID:23627352] |
ChEMBL | In vitro inhibition of human dihydrofolate reductase | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1995) 38: 3608-3616 [PMID:7658448] |
dihydrofolate reductase/Dihydrofolate reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2] | ||||||||
ChEMBL | Compound was tested for inhibition activity against rat liver lipophilic Dihydrofolate reductase (DHFR). | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1998) 41: 913-918 [PMID:9526565] |
ChEMBL | The ability to inhibit rat liver Dihydrofolate reductase was tested | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1999) 42: 1007-1017 [PMID:10090784] |
ChEMBL | Inhibition of rat liver dihydrofolate reductase | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (2008) 51: 6195-6200 [PMID:18771252] |
ChEMBL | Inhibitory concentration against dihydrofolate reductase DHFR from rat liver. | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (2001) 44: 2391-2402 [PMID:11448221] |
ChEMBL | Inhibition of rat liver DHFR | B | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (2013) 56: 4422-4441 [PMID:23627352] |
ChEMBL | Inhibitory concentration against dihydrofolate reductase of rat liver | B | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (2004) 47: 1475-1486 [PMID:14998335] |
ChEMBL | Inhibitory activity against rat dihydrofolate reductase | B | 8.48 | pIC50 | 3.3 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078] |
ChEMBL | Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range: 2.9-3.9 | B | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (2004) 47: 2475-2485 [PMID:15115391] |
ChEMBL | Inhibition Dihydrohydrofolate reductase(DHFR) of rat liver | B | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (2003) 46: 1726-1736 [PMID:12699390] |
ChEMBL | Inhibitory concentration against rat DHFR | B | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (2005) 48: 4420-4431 [PMID:15974594] |
ChEMBL | Inhibitory activity against rat liver Dihydrofolate reductase | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1995) 38: 745-752 [PMID:7877140] |
ChEMBL | Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl) | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1999) 42: 2447-2455 [PMID:10395486] |
ChEMBL | Inhibition of dihydrofolate reductase from rat liver. | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2003) 46: 5074-5082 [PMID:14584957] |
ChEMBL | Inhibitory concentration against Rat liver Dihydrofolate reductase | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1997) 40: 1930-1936 [PMID:9191971] |
ChEMBL | Inhibitory concentration against rat liver dihydrofolate reductase (DHFR) | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1997) 40: 3032-3039 [PMID:9301665] |
ChEMBL | Inhibitory activity against rat DHFR* | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2003) 46: 1726-1736 [PMID:12699390] |
ChEMBL | Concentration inhibiting rat liver dihydrofolate reductase. | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1995) 38: 2615-2620 [PMID:7629801] |
ChEMBL | Inhibitory activity against rat liver dihydrofolate reductase | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1996) 39: 1271-1280 [PMID:8632434] |
ChEMBL | Inhibitory concentration against Dihydrofolate reductase from Rat liver (rl) | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1997) 40: 470-478 [PMID:9046337] |
ChEMBL | Inhibition of rat liver dihydrofolate reductase | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1993) 36: 3437-3443 [PMID:8230134] |
ChEMBL | Inhibition of Dihydrofolate Reductase of Rat Liver. | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1997) 40: 479-485 [PMID:9046338] |
ChEMBL | Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 uM dihydrofolic acid as substrate | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1997) 40: 3040-3048 [PMID:9301666] |
ChEMBL | Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1998) 41: 4533-4541 [PMID:9804692] |
ChEMBL | Inhibition of rat liver dihydrofolate reductase | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1997) 40: 3032-3039 [PMID:9301665] |
ChEMBL | Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liver | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2002) 45: 233-241 [PMID:11754594] |
ChEMBL | Inhibition of Dihydrofolate reductase (DHFR) of in rat liver | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1994) 37: 4522-4528 [PMID:7799402] |
ChEMBL | Inhibitory activity against rat liver dihydrofolate reductase. | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1996) 39: 1836-1845 [PMID:8627607] |
ChEMBL | Inhibition of rat liver dihydrofolate reductase. | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1993) 36: 3103-3112 [PMID:8230096] |
ChEMBL | Inhibitory activity against Dihydrofolate reductase from rat liver | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (1995) 38: 1778-1785 [PMID:7752201] |
ChEMBL | Inhibition against Dihydrofolate reductase in rat liver | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1997) 40: 1173-1177 [PMID:9089339] |
ChEMBL | Inhibition of rat liver Dihydrofolate reductase | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1995) 38: 2158-2165 [PMID:7783147] |
Dihydrofolate reductase in Pneumocystis jirovecii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2057] [UniProtKB: Q9UUP5] | ||||||||
ChEMBL | Inhibition of Pneumocystis jirovecii recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPH | B | 7.39 | pIC50 | 41 | nM | IC50 | Bioorg Med Chem (2018) 26: 2640-2650 [PMID:29691153] |
Dihydrofolate reductase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2576] [UniProtKB: P07807] | ||||||||
ChEMBL | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1996) 39: 1836-1845 [PMID:8627607] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]