piritrexim [Ligand Id: 7414] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL7492 (Bw 301u, Bw-301u, BW-301U, Piritrexim, TCMDC-137235)
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  • Dihydrofolate reductase in Escherichia coli [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4]
  • Dihydrofolate reductase in Lactobacillus casei [ChEMBL: CHEMBL2902] [UniProtKB: P00381]
  • Dihydrofolate reductase in Mycobacterium avium [ChEMBL: CHEMBL5457] [UniProtKB: O30463]
  • Dihydrofolate reductase in Pneumocystis carinii [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
  • Dihydrofolate reductase in Candida albicans [ChEMBL: CHEMBL2329] [UniProtKB: P22906]
  • Dihydrofolate reductase in Toxoplasma gondii [ChEMBL: CHEMBL2425] [UniProtKB: Q07422]
  • dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
  • dihydrofolate reductase/Dihydrofolate reductase in Rat [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2]
  • Dihydrofolate reductase in Pneumocystis jirovecii [ChEMBL: CHEMBL2057] [UniProtKB: Q9UUP5]
  • Dihydrofolate reductase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL2576] [UniProtKB: P07807]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Bacterial dihydrofolate reductase in Bacteria (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2364669] [UniProtKB: P0ABQ4]
ChEMBL In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. B 7.51 pIC50 31 nM IC50 J Med Chem (2002) 45: 233-241 [PMID:11754594]
Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4]
ChEMBL Inhibition of dihydrofolate reductase in pneumocystis carinii. B 7.42 pIC50 38 nM IC50 J Med Chem (1993) 36: 3103-3112 [PMID:8230096]
ChEMBL Inhibition of dihydrofolate reductase from pneumocystis carinii. B 7.51 pIC50 31 nM IC50 J Med Chem (2003) 46: 5074-5082 [PMID:14584957]
ChEMBL Inhibition of dihydrofolate reductase in Toxoplasma gondii. B 7.96 pIC50 11 nM IC50 J Med Chem (1993) 36: 3103-3112 [PMID:8230096]
ChEMBL Inhibition of dihydrofolate reductase from Toxoplasma gondii. B 7.96 pIC50 11 nM IC50 J Med Chem (2003) 46: 5074-5082 [PMID:14584957]
Dihydrofolate reductase in Lactobacillus casei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2902] [UniProtKB: P00381]
ChEMBL Inhibitory activity against dihydrofolate reductase in mammalians. (high potency) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
Dihydrofolate reductase in Mycobacterium avium (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5457] [UniProtKB: O30463]
ChEMBL Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium B 9.21 pIC50 0.61 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Inhibitory concentration against Mycobacterium avium dihydrofolate reductase B 9.21 pIC50 0.61 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range: 0.53-0.70 B 9.21 pIC50 0.61 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium B 9.21 pIC50 0.61 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory concentration against Mycobacterium avium DHFR B 9.21 pIC50 0.61 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
ChEMBL Binding affinity was reported with purified recombinant Pneumocystis carinii Dihydrofolate reductase B 9.84 pKi 0.14 nM Ki J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Inhibitory concentration against Dihydrofolate reductase from Pneumocystis carinii (pc) B 7.42 pIC50 38 nM IC50 J Med Chem (1997) 40: 470-478 [PMID:9046337]
ChEMBL Inhibition of Pneumocystis carinii (pc) Dihydrofolate reductase B 7.42 pIC50 38 nM IC50 J Med Chem (1995) 38: 2158-2165 [PMID:7783147]
ChEMBL Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii(pc) B 7.42 pIC50 38 nM IC50 J Med Chem (1999) 42: 2447-2455 [PMID:10395486]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii B 7.42 pIC50 38 nM IC50 J Med Chem (1995) 38: 1778-1785 [PMID:7752201]
ChEMBL Inhibition against Dihydrofolate reductase in Pneumocystis carinii B 7.42 pIC50 38 nM IC50 J Med Chem (1997) 40: 1173-1177 [PMID:9089339]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.42 pIC50 38 nM IC50 J Med Chem (1993) 36: 3437-3443 [PMID:8230134]
ChEMBL Inhibition of Dihydrofolate Reductase of Pneumocystis carinii. B 7.42 pIC50 38 nM IC50 J Med Chem (1997) 40: 479-485 [PMID:9046338]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.46 pIC50 34.3 nM IC50 J Med Chem (2008) 51: 6195-6200 [PMID:18771252]
ChEMBL Inhibitory concentration against dihydrofolate reductase dihydrofolate reductase from Pneumocystis carinii. B 7.47 pIC50 34 nM IC50 J Med Chem (2001) 44: 2391-2402 [PMID:11448221]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibition of Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii. (high potency) B 7.51 pIC50 31 nM IC50 J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Compound was tested for inhibition activity against pneumocystis carinii (Pneumocystis carinii) Dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1998) 41: 913-918 [PMID:9526565]
ChEMBL Inhibitory activity against Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory activity against Pneumocystis carinii Dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibitory concentration against Pneumocystis carinii Dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 1930-1936 [PMID:9191971]
ChEMBL The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was tested B 7.51 pIC50 31 nM IC50 J Med Chem (1999) 42: 1007-1017 [PMID:10090784]
ChEMBL Concentration inhibiting Pneumocystis carinii dihydrofolate reductase B 7.51 pIC50 31 nM IC50 J Med Chem (1995) 38: 2615-2620 [PMID:7629801]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 uM dihydrofolic acid as substrate B 7.51 pIC50 31 nM IC50 J Med Chem (1997) 40: 3040-3048 [PMID:9301666]
ChEMBL Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis carinii B 7.51 pIC50 31 nM IC50 J Med Chem (1998) 41: 4533-4541 [PMID:9804692]
ChEMBL Inhibition of Dihydrofolate reductase of Pneumocystis carinii B 7.51 pIC50 31 nM IC50 J Med Chem (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against Pneumocystis. carinii DHFR* B 7.51 pIC50 31 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii at 37 centigrade. B 7.72 pIC50 19 nM IC50 J Med Chem (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Inhibition of Pneumocystis carinii DHFR by spectrophotometric assay B 7.72 pIC50 19 nM IC50 Eur J Med Chem (2015) 95: 76-95 [PMID:25794791]
ChEMBL Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis carinii B 7.89 pIC50 13 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory concentration against Pneumocystis carinii dihydrofolate reductase B 7.89 pIC50 13 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Inhibitory concentration against Pneumocystis carinii DHFR B 7.89 pIC50 13 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
ChEMBL Inhibitory concentration against dihydrofolate reductace enzyme of Pneumocystis carinii B 7.89 pIC50 13 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range: 9.0-17 B 7.89 pIC50 13 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibition of Pneumocystis carinii DHFR B 7.89 pIC50 13 nM IC50 J Med Chem (2013) 56: 4422-4441 [PMID:23627352]
Dihydrofolate reductase in Candida albicans (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2329] [UniProtKB: P22906]
ChEMBL Inhibition of Dihydrofolate reductase enzyme from Candida albicans B 8.72 pKi 1.9 nM Ki J Med Chem (1996) 39: 892-903 [PMID:8632413]
ChEMBL Inhibition of dihydrofolate reductase in Candida albicans (in vitro). B 7.4 pIC50 40 nM IC50 J Med Chem (1995) 38: 3608-3616 [PMID:7658448]
Dihydrofolate reductase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2425] [UniProtKB: Q07422]
ChEMBL Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii B 7.37 pIC50 43 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibition of Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay B 7.77 pIC50 17 nM IC50 Eur J Med Chem (2015) 95: 76-95 [PMID:25794791]
ChEMBL Inhibitory activity against Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory activity against Toxoplasma gondii Dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibitory concentration against Toxoplasma gondii Dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 1930-1936 [PMID:9191971]
ChEMBL The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was tested B 7.77 pIC50 17 nM IC50 J Med Chem (1999) 42: 1007-1017 [PMID:10090784]
ChEMBL Concentration inhibiting Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1995) 38: 2615-2620 [PMID:7629801]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 uM dihydrofolic acid as substrate B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 3040-3048 [PMID:9301666]
ChEMBL Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondii B 7.77 pIC50 17 nM IC50 J Med Chem (1998) 41: 4533-4541 [PMID:9804692]
ChEMBL Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg) B 7.77 pIC50 17 nM IC50 J Med Chem (2002) 45: 233-241 [PMID:11754594]
ChEMBL Inhibition of Dihydrofolate reductase of Toxoplasma gondii B 7.77 pIC50 17 nM IC50 J Med Chem (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against Toxoplasma gondii DHFR* B 7.77 pIC50 17 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibition of Toxoplasma gondii dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Compound was tested for inhibition activity against Toxoplasma gondii (Toxoplasma gondii) Dihydrofolate reductase B 7.77 pIC50 17 nM IC50 J Med Chem (1998) 41: 913-918 [PMID:9526565]
ChEMBL Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. B 7.77 pIC50 17 nM IC50 J Med Chem (1996) 39: 1836-1845 [PMID:8627607]
ChEMBL Inhibitory concentration against dihydrofolate reductase DHFR from Toxoplasma gondii B 7.77 pIC50 17 nM IC50 J Med Chem (2001) 44: 2391-2402 [PMID:11448221]
ChEMBL Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii B 7.96 pIC50 11 nM IC50 J Med Chem (1995) 38: 1778-1785 [PMID:7752201]
ChEMBL Inhibition of Toxoplasma gondii dihydrofolate reductase B 7.96 pIC50 11 nM IC50 J Med Chem (1993) 36: 3437-3443 [PMID:8230134]
ChEMBL Inhibition of Dihydrofolate Reductase of Toxoplasma gondii. B 7.96 pIC50 11 nM IC50 J Med Chem (1997) 40: 479-485 [PMID:9046338]
ChEMBL Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (tg) B 7.96 pIC50 11 nM IC50 J Med Chem (1997) 40: 470-478 [PMID:9046337]
ChEMBL Inhibition of dihydrofolate reductase (DHFR) from Toxoplasma gondii(tg) B 7.96 pIC50 11 nM IC50 J Med Chem (1999) 42: 2447-2455 [PMID:10395486]
ChEMBL Inhibition of Toxoplasma gondii (tc) Dihydrofolate reductase B 8 pIC50 10 nM IC50 J Med Chem (1995) 38: 2158-2165 [PMID:7783147]
ChEMBL Inhibition against Dihydrofolate reductase in Toxoplasma gondii B 8 pIC50 10 nM IC50 J Med Chem (1997) 40: 1173-1177 [PMID:9089339]
ChEMBL Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range: 4.0-4.6 B 8.37 pIC50 4.3 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii B 8.37 pIC50 4.3 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Inhibitory concentration against Toxoplasma gondii dihydrofolate reductase B 8.37 pIC50 4.3 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Inhibitory concentration against Toxoplasma gondii DHFR B 8.37 pIC50 4.3 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductase B 7.42 pKi 38 nM Ki J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibitory activity against Wild-type human DHFR B 7.48 pKi 33 nM Ki J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibition of human recombinant Dihydrofolate reductase enzyme B 10.6 pKi 0.03 nM Ki J Med Chem (1996) 39: 892-903 [PMID:8632413]
ChEMBL Inhibition of human recombinant DHFR B 8.52 pIC50 3 nM IC50 J Med Chem (2013) 56: 4422-4441 [PMID:23627352]
ChEMBL In vitro inhibition of human dihydrofolate reductase B 8.7 pIC50 2 nM IC50 J Med Chem (1995) 38: 3608-3616 [PMID:7658448]
dihydrofolate reductase/Dihydrofolate reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2]
ChEMBL Compound was tested for inhibition activity against rat liver lipophilic Dihydrofolate reductase (DHFR). B 7.82 pIC50 15 nM IC50 J Med Chem (1998) 41: 913-918 [PMID:9526565]
ChEMBL The ability to inhibit rat liver Dihydrofolate reductase was tested B 7.82 pIC50 15 nM IC50 J Med Chem (1999) 42: 1007-1017 [PMID:10090784]
ChEMBL Inhibition of rat liver dihydrofolate reductase B 8.36 pIC50 4.4 nM IC50 J Med Chem (2008) 51: 6195-6200 [PMID:18771252]
ChEMBL Inhibitory concentration against dihydrofolate reductase DHFR from rat liver. B 8.36 pIC50 4.4 nM IC50 J Med Chem (2001) 44: 2391-2402 [PMID:11448221]
ChEMBL Inhibition of rat liver DHFR B 8.48 pIC50 3.3 nM IC50 J Med Chem (2013) 56: 4422-4441 [PMID:23627352]
ChEMBL Inhibitory concentration against dihydrofolate reductase of rat liver B 8.48 pIC50 3.3 nM IC50 J Med Chem (2004) 47: 1475-1486 [PMID:14998335]
ChEMBL Inhibitory activity against rat dihydrofolate reductase B 8.48 pIC50 3.3 nM IC50 Bioorg Med Chem Lett (2004) 14: 1811-1815 [PMID:15026078]
ChEMBL Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range: 2.9-3.9 B 8.48 pIC50 3.3 nM IC50 J Med Chem (2004) 47: 2475-2485 [PMID:15115391]
ChEMBL Inhibition Dihydrohydrofolate reductase(DHFR) of rat liver B 8.48 pIC50 3.3 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Inhibitory concentration against rat DHFR B 8.48 pIC50 3.3 nM IC50 J Med Chem (2005) 48: 4420-4431 [PMID:15974594]
ChEMBL Inhibitory activity against rat liver Dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1999) 42: 2447-2455 [PMID:10395486]
ChEMBL Inhibition of dihydrofolate reductase from rat liver. B 8.82 pIC50 1.5 nM IC50 J Med Chem (2003) 46: 5074-5082 [PMID:14584957]
ChEMBL Inhibitory concentration against Rat liver Dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 1930-1936 [PMID:9191971]
ChEMBL Inhibitory concentration against rat liver dihydrofolate reductase (DHFR) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibitory activity against rat DHFR* B 8.82 pIC50 1.5 nM IC50 J Med Chem (2003) 46: 1726-1736 [PMID:12699390]
ChEMBL Concentration inhibiting rat liver dihydrofolate reductase. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 2615-2620 [PMID:7629801]
ChEMBL Inhibitory activity against rat liver dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory concentration against Dihydrofolate reductase from Rat liver (rl) B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 470-478 [PMID:9046337]
ChEMBL Inhibition of rat liver dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1993) 36: 3437-3443 [PMID:8230134]
ChEMBL Inhibition of Dihydrofolate Reductase of Rat Liver. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 479-485 [PMID:9046338]
ChEMBL Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 uM dihydrofolic acid as substrate B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 3040-3048 [PMID:9301666]
ChEMBL Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (1998) 41: 4533-4541 [PMID:9804692]
ChEMBL Inhibition of rat liver dihydrofolate reductase B 8.82 pIC50 1.5 nM IC50 J Med Chem (1997) 40: 3032-3039 [PMID:9301665]
ChEMBL Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (2002) 45: 233-241 [PMID:11754594]
ChEMBL Inhibition of Dihydrofolate reductase (DHFR) of in rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against rat liver dihydrofolate reductase. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1996) 39: 1836-1845 [PMID:8627607]
ChEMBL Inhibition of rat liver dihydrofolate reductase. B 8.82 pIC50 1.5 nM IC50 J Med Chem (1993) 36: 3103-3112 [PMID:8230096]
ChEMBL Inhibitory activity against Dihydrofolate reductase from rat liver B 8.82 pIC50 1.5 nM IC50 J Med Chem (1995) 38: 1778-1785 [PMID:7752201]
ChEMBL Inhibition against Dihydrofolate reductase in rat liver B 9 pIC50 1 nM IC50 J Med Chem (1997) 40: 1173-1177 [PMID:9089339]
ChEMBL Inhibition of rat liver Dihydrofolate reductase B 9 pIC50 1 nM IC50 J Med Chem (1995) 38: 2158-2165 [PMID:7783147]
Dihydrofolate reductase in Pneumocystis jirovecii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2057] [UniProtKB: Q9UUP5]
ChEMBL Inhibition of Pneumocystis jirovecii recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPH B 7.39 pIC50 41 nM IC50 Bioorg Med Chem (2018) 26: 2640-2650 [PMID:29691153]
Dihydrofolate reductase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2576] [UniProtKB: P07807]
ChEMBL Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. B 7.51 pIC50 31 nM IC50 J Med Chem (1996) 39: 1836-1845 [PMID:8627607]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]