zenarestat [Ligand Id: 7418] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL10413 (CI-1014, FK-366, FR-74366, Zenarestat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
| ChEMBL | In vitro inhibition of recombinant human aldehyde reductase | B | 5 | pIC50 | 9900 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| GtoPdb | In vitro inhibition of recombinant human aldehyde reductase | - | 5 | pIC50 | 9900 | nM | IC50 | J Med Chem (2005) 48: 3141-52 [PMID:15857120] |
| ChEMBL | Inhibition of aldose reductase | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem (2007) 15: 7865-7877 [PMID:17870536] |
| ChEMBL | Inhibitory Activity against Human recombinant Aldose Reductase (wild type) | B | 7.37 | pIC50 | 42.4 | nM | IC50 | J Med Chem (2000) 43: 1062-1070 [PMID:10737739] |
| ChEMBL | In vitro inhibition of recombinant human aldose reductase expressed in Escherichia coli | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| Aldose reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4559] [UniProtKB: P80276] | ||||||||
| ChEMBL | Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1677-1682 |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibitory activity against purified rat lens aldose reductase (RLAR) | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (1994) 37: 787-792 [PMID:8145228] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
