TMP269 [Ligand Id: 7491] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3110004 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of human HDAC1 using p53 (379 to 382 residues) (RHKKAc) as substrate measured after 2 hrs by cheng-Prusoff analysis | B | 4.64 | pKi | >23000 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] | ||||||||
| ChEMBL | Inhibition of HDAC10 (unknown origin) | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of HDAC10 (unknown origin) | B | 6.68 | pIC50 | 210 | nM | IC50 | Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126] |
| histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] | ||||||||
| ChEMBL | Inhibition of human HDAC11 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 4.72 | pKi | >19000 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of human HDAC2 using p53 (379 to 382 residues) (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 4.72 | pKi | >19000 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assay | B | 4.37 | pIC50 | >43000 | nM | IC50 | J Med Chem (2013) 56: 9934-9954 [PMID:24261862] |
| histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] | ||||||||
| ChEMBL | Inhibition of human HDAC3/NcoR2 using p53 residues 379-382 (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 4.37 | pKi | >43000 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
| ChEMBL | Inhibition of C-terminal His-tagged/N-terminal GST-tagged recombinant human HDAC4 (627 to 1084 residues) expressed in Baculovirus infected insect cells using Boc-Lys(TFa)-AMC as substrate preincubated for 5 mins followed by substrate addition and further incubation for 90 mins measured after 15 mins by microplate reader based fluorescence assay | B | 5.75 | pKi | 1770 | nM | Ki | Bioorg Med Chem (2019) 27: 115036-115036 [PMID:31431326] |
| ChEMBL | Inhibition of human HDAC4 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 6.9 | pKi | 126 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of HDAC4 (unknown origin) using fluorogenic substrate after 1 to 2 hrs by fluorescence assay | B | 6.45 | pIC50 | 353 | nM | IC50 | Eur J Med Chem (2018) 143: 2005-2014 [PMID:29150335] |
| ChEMBL | Inhibition of recombinant human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate by homogeneous fluorescence release assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2019) 161: 277-291 [PMID:30366254] |
| ChEMBL | Inhibition of recombinant human N-terminal GST-tagged and C-terminal His-tagged HDAC4 expressed in baculovirus infected insect cells using fluorogenic HDAC class2a as substrate measured after 1 to 2 hrs by fluorescence assay | B | 6.61 | pIC50 | 244 | nM | IC50 | J Med Chem (2020) 63: 4256-4292 [PMID:32212730] |
| ChEMBL | Inhibition of HDAC4 (unknown origin) | B | 6.74 | pIC50 | 180 | nM | IC50 | Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126] |
| GtoPdb | - | - | 6.8 | pIC50 | 157 | nM | IC50 | Nat Chem Biol (2013) 9: 319-25 [PMID:23524983] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incubated for 60 mins by fluorescence assay | B | 6.87 | pIC50 | 134.4 | nM | IC50 | Eur J Med Chem (2016) 116: 126-135 [PMID:27060764] |
| ChEMBL | Inhibition of human recombinant HDAC4 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2013) 56: 9934-9954 [PMID:24261862] |
| ChEMBL | Inhibition of recombinant human HDAC4 using fluorogenic substrate by fluorescence assay | B | 6.9 | pIC50 | 127 | nM | IC50 | Eur J Med Chem (2017) 125: 1268-1278 [PMID:27886544] |
| histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] | ||||||||
| ChEMBL | Inhibition of human HDAC5 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 7.1 | pKi | 80 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of C-terminal His-tagged human HDAC5 (656-1122 residues) expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mins by fluorescence based assay | B | 6 | pIC50 | 990 | nM | IC50 | Eur J Med Chem (2017) 140: 392-402 [PMID:28987602] |
| ChEMBL | Inhibition of recombinant human C-terminal His-fusion tagged HDAC5 (657 to 1123 residues) expressed in baculovirus infected insect cells using fluorogenic HDAC class2a as substrate measured after 1 to 2 hrs by fluorescence assay | B | 6.48 | pIC50 | 333 | nM | IC50 | J Med Chem (2020) 63: 4256-4292 [PMID:32212730] |
| ChEMBL | Inhibition of recombinant human HDAC5 using fluorogenic substrate by fluorescence assay | B | 6.58 | pIC50 | 263 | nM | IC50 | Eur J Med Chem (2017) 125: 1268-1278 [PMID:27886544] |
| ChEMBL | Inhibition of HDAC5 (unknown origin) | B | 6.96 | pIC50 | 110 | nM | IC50 | Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126] |
| ChEMBL | Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incubated for 60 mins by fluorescence assay | B | 6.96 | pIC50 | 108.4 | nM | IC50 | Eur J Med Chem (2016) 116: 126-135 [PMID:27060764] |
| GtoPdb | - | - | 7.01 | pIC50 | 97 | nM | IC50 | Nat Chem Biol (2013) 9: 319-25 [PMID:23524983] |
| ChEMBL | Inhibition of human recombinant HDAC5 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2013) 56: 9934-9954 [PMID:24261862] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of human HDAC6 using p53 residues 379-382 (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of human recombinant full length HDAC6 after 60 mins by fluorescence assay | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2013) 56: 9934-9954 [PMID:24261862] |
| ChEMBL | Inhibition of HDAC6 (unknown origin) | B | 6.05 | pIC50 | 890 | nM | IC50 | Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126] |
| histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] | ||||||||
| ChEMBL | Inhibition of human HDAC7 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 7.44 | pKi | 36 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of recombinant human HDAC7 using fluorogenic substrate by fluorescence assay | B | 6.95 | pIC50 | 112 | nM | IC50 | Eur J Med Chem (2017) 125: 1268-1278 [PMID:27886544] |
| ChEMBL | Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in baculovirus infected insect cells using fluorogenic HDAC class2a as substrate measured after 1 to 2 hrs by fluorescence assay | B | 6.97 | pIC50 | 108 | nM | IC50 | J Med Chem (2020) 63: 4256-4292 [PMID:32212730] |
| ChEMBL | Inhibition of HDAC7 (unknown origin) | B | 7.22 | pIC50 | 60 | nM | IC50 | Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126] |
| GtoPdb | - | - | 7.37 | pIC50 | 43 | nM | IC50 | Nat Chem Biol (2013) 9: 319-25 [PMID:23524983] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incubated for 60 mins by fluorescence assay | B | 7.39 | pIC50 | 40.85 | nM | IC50 | Eur J Med Chem (2016) 116: 126-135 [PMID:27060764] |
| ChEMBL | Inhibition of human recombinant HDAC7 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2013) 56: 9934-9954 [PMID:24261862] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| ChEMBL | Inhibition of human HDAC8 using p53 residues 379-382 (RHKAcKAc) as substrate as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 5.4 | pKi | 4000 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of human recombinant full length HDAC8 using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | B | 5.44 | pIC50 | 3600 | nM | IC50 | J Med Chem (2013) 56: 9934-9954 [PMID:24261862] |
| histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] | ||||||||
| ChEMBL | Inhibition of human HDAC9 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysis | B | 7.72 | pKi | 19 | nM | Ki | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of HDAC9 (unknown origin) using fluorogenic HDAC class 2a as substrate measured after 1 to 2 hrs by fluorescence assay | B | 7.31 | pIC50 | 49 | nM | IC50 | J Med Chem (2020) 63: 4256-4292 [PMID:32212730] |
| ChEMBL | Inhibition of human recombinant HDAC9 using trifluoroacetyl lysine as substrate | B | 7.63 | pIC50 | 23.24 | nM | IC50 | Eur J Med Chem (2016) 116: 126-135 [PMID:27060764] |
| GtoPdb | - | - | 7.64 | pIC50 | 23 | nM | IC50 | Nat Chem Biol (2013) 9: 319-25 [PMID:23524983] |
| ChEMBL | Inhibition of human recombinant HDAC9 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2013) 56: 9934-9954 [PMID:24261862] |
| ChEMBL | Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence assay | B | 7.71 | pIC50 | 19.4 | nM | IC50 | Eur J Med Chem (2017) 125: 1268-1278 [PMID:27886544] |
| ChEMBL | Inhibition of HDAC9 (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2021) 225: 113790-113790 [PMID:34454126] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
