benzamidine [Ligand Id: 7566] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL20936 (Benzamidine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acrosin in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243910] [UniProtKB: P08001] | ||||||||
| ChEMBL | Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis | B | 5.4 | pKi | 4000 | nM | Ki | J Med Chem (1978) 21: 1132-1136 [PMID:722718] |
| aldehyde oxidase 1/Aldehyde oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3257] [GtoPdb: 3186] [UniProtKB: Q06278] | ||||||||
| ChEMBL | Mixed type inhibition of human AOX assessed as inhibitor dissociation constant by measuring changes in intercept of the double reciprocal plot using phenanthridine as substrate by Michaelis-Menten analysis | B | 2.79 | pKi | 1620 | uM | Kii | J Med Chem (2021) 64: 13025-13037 [PMID:34415167] |
| coagulation factor VII/coagulation factor III, tissue factor/Coagulation factor VII/tissue factor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095194] [GtoPdb: 2363, 3192] [UniProtKB: P08709, P13726] | ||||||||
| ChEMBL | Inhibition of human soluble tissue factor/factor VIIa expressed in Origami B (DE3) using D-Ile-Pro-Arg-pNA as substrate after 30 mins by spectrophotometric analysis | B | 3.62 | pKi | 240000 | nM | Ki | J Med Chem (2015) 58: 2799-2808 [PMID:25764119] |
| coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
| ChEMBL | Binding affinity was evaluated against Coagulation factor X | B | 6.39 | pKi | 410 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 1877-1882 [PMID:9873451] |
| ChEMBL | Inhibitory concentration against human Coagulation factor Xa (fXa) | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2002) 45: 1221-1232 [PMID:11881991] |
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Binding affinity to thrombin (unknown origin) by displacement titration based isothermal titration colorimetry | B | 3.34 | pKd | 455000 | nM | Kd | J Med Chem (2015) 58: 6960-6971 [PMID:26270568] |
| ChEMBL | Binding affinity to thrombin (unknown origin) by direct isothermal titration colorimetry | B | 3.45 | pKd | 355000 | nM | Kd | J Med Chem (2015) 58: 6960-6971 [PMID:26270568] |
| ChEMBL | Binding affinity to thrombin (unknown origin) | B | 3.45 | pKd | 355000 | nM | Kd | Medchemcomm (2016) 7: 332-337 |
| ChEMBL | Binding affinity to thrombin (unknown origin) | B | 3.59 | pKi | 258000 | nM | Ki | J Med Chem (2015) 58: 6960-6971 [PMID:26270568] |
| ChEMBL | Binding affinity against human thrombin | B | 5.91 | pKi | 1240 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
| ChEMBL | Binding affinity against human thrombin | B | 5.91 | pKi | 1240 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
| ChEMBL | Inhibitory Activity against human thrombin | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2000) 43: 3033-3044 [PMID:10956211] |
| ChEMBL | In vitro binding affinity by measuring the inhibition of human thrombin | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (1994) 37: 3889-3901 [PMID:7966150] |
| serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] | ||||||||
| ChEMBL | Binding affinity against trypsin | B | 4.74 | pKd | -4.74 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
| Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
| ChEMBL | Inhibitory activity against bovine trypsin expressed as dissociation constant | B | 4.41 | pKi | 39000 | nM | Ki | J Med Chem (1998) 41: 5445-5456 [PMID:9876114] |
| ChEMBL | Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5. | B | 4.46 | pKi | 35000 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 1283-1288 |
| ChEMBL | Competitive inhibition of bovine beta trypsin using Bz-Arg-NH-Np as substrate at pH 7 at 30 degC | B | 4.49 | pKi | 32000 | nM | Ki | Bioorg Med Chem (2020) 28: 115612-115612 [PMID:32690267] |
| ChEMBL | Inhibitory concentration against bovine trypsin | B | 4.7 | pKi | 20000 | nM | Ki | J Med Chem (2002) 45: 1221-1232 [PMID:11881991] |
| ChEMBL | Binding affinity against bovine trypsin | B | 4.74 | pKi | 18400 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
| ChEMBL | Binding affinity against bovine trypsin | B | 4.74 | pKi | 18400 | nM | Ki | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
| ChEMBL | In vitro binding affinity by measuring the inhibition of bovine trypsin | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (1994) 37: 3889-3901 [PMID:7966150] |
| ChEMBL | Inhibitory Activity against bovine trypsin | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2000) 43: 3033-3044 [PMID:10956211] |
| Trypsin II in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4472] [UniProtKB: Q29463] | ||||||||
| ChEMBL | log Kd (Binding affinity against specified protein) value of the compound | B | 1.83 | pKd | -1.83 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
