ChEMBL ligand: CHEMBL2431768 (Lcl 161, Lcl-161, Lcl161, LCL161, Nvp-lcl 161)
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] There should be some charts here, you may need to enable JavaScript!
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
ChEMBL	Binding affinity to cIAP1-BIR3 domain (unknown origin)	B	7.98	pKd	10.4	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Inhibition of His-thrombin-TEV-tagged cIAP1 BIR2 domain (174 to 256) (unknown origin) after 1 hr by TR-FRET assay	B	5.57	pIC50	2720	nM	IC50	J Med Chem (2013) 56: 7772-7787 [PMID:24083782]
ChEMBL	Inhibition of cIAP1 BIR2 domain (unknown origin)	B	5.67	pIC50	2140	nM	IC50	J Med Chem (2013) 56: 7788-7803 [PMID:24093940]
ChEMBL	Inhibition of cIAP1 BIR3 domain (unknown origin)	B	7.21	pIC50	61	nM	IC50	J Med Chem (2013) 56: 7788-7803 [PMID:24093940]
ChEMBL	Inhibition of His-thrombin-TEV-tagged cIAP1 BIR3 domain (260 to 352) (unknown origin) after 1 hr by TR-FRET assay	B	7.24	pIC50	58	nM	IC50	J Med Chem (2013) 56: 7772-7787 [PMID:24083782]
GtoPdb	Assay uses recombinantly expressed BIR3 domain of cIAP1	-	7.24	pIC50	58	nM	IC50	J Med Chem (2013) 56: 7772-87 [PMID:24083782]
ChEMBL	Inhibition of N-terminal 6x-His-tagged recombinant human cIAP1-BIR3 (258 to 363 residues) expressed in Escherichia coli incubated for 2 hrs after 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA	B	7.68	pIC50	21	nM	IC50	J Med Chem (2019) 62: 9188-9200 [PMID:31550155]
ChEMBL	Inhibition of N-terminal 6x-His-tagged recombinant human cIAP1-BIR3 (258 to 363 residues) expressed in Escherichia coli incubated for 2 hrs without 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA	B	7.73	pIC50	18.6	nM	IC50	J Med Chem (2019) 62: 9188-9200 [PMID:31550155]
ChEMBL	Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrs	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
ChEMBL	Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrs	B	9.4	pEC50	0.4	nM	EC50	J Med Chem (2017) 60: 4611-4625 [PMID:28492317]
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489]
ChEMBL	Binding affinity to cIAP2-BIR3 domain (unknown origin)	B	7.89	pKd	12.9	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Inhibition of N-terminal 6x-His-tagged recombinant human cIAP2-BIR3 (244 to 349 residues) expressed in Escherichia coli incubated for 2 hrs after 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA	B	7.72	pIC50	19	nM	IC50	J Med Chem (2019) 62: 9188-9200 [PMID:31550155]
ChEMBL	Inhibition of N-terminal 6x-His-tagged recombinant human cIAP2-BIR3 (244 to 349 residues) expressed in Escherichia coli incubated for 2 hrs without 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA	B	7.96	pIC50	11	nM	IC50	J Med Chem (2019) 62: 9188-9200 [PMID:31550155]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL	Binding affinity to XIAP-BIR3 domain (241 to 356 residues) (unknown origin) by fluorescence polarization-based competition assay	B	7.28	pKd	52.7	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Inhibition of His-tagged XIAP BIR2 domain (124 to 240) (unknown origin) after 1 hr by TR-FRET assay	B	5.98	pIC50	1050	nM	IC50	J Med Chem (2013) 56: 7772-7787 [PMID:24083782]
ChEMBL	Inhibition of XIAP BIR2 domain (unknown origin)	B	5.98	pIC50	1040	nM	IC50	J Med Chem (2013) 56: 7788-7803 [PMID:24093940]
ChEMBL	Displacement of biotinylated AVPF from N-terminal His tagged recombinant human XIAP-BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 8 hrs by DELFIA	B	7.28	pIC50	53	nM	IC50	J Med Chem (2019) 62: 5616-5627 [PMID:31095386]
ChEMBL	Inhibition of N-terminal His-tagged human XIAP-BIR3 (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS incubated for 2 hrs without 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA	B	7.3	pIC50	50	nM	IC50	J Med Chem (2019) 62: 9188-9200 [PMID:31550155]
ChEMBL	Displacement of biotinylated AVPF from N-terminal His tagged recombinant human XIAP-BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 2 hrs by DELFIA	B	7.32	pIC50	48	nM	IC50	J Med Chem (2019) 62: 5616-5627 [PMID:31095386]
ChEMBL	Inhibition of N-terminal His-tagged human XIAP-BIR3 (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS incubated for 2 hrs after 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA	B	7.4	pIC50	40	nM	IC50	J Med Chem (2019) 62: 9188-9200 [PMID:31550155]
ChEMBL	Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by immunoprecipitation assay	B	7.46	pIC50	35	nM	IC50	J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
GtoPdb	Assay uses recombinantly expressed BIR3 domain of XIAP	-	7.52	pIC50	30	nM	IC50	J Med Chem (2013) 56: 7772-87 [PMID:24083782]
ChEMBL	Inhibition of His-tagged XIAP BIR3 domain (241 to 356) (unknown origin) after 1 hr by TR-FRET assay	B	7.52	pIC50	30	nM	IC50	J Med Chem (2013) 56: 7772-7787 [PMID:24083782]
ChEMBL	Inhibition of XIAP BIR3 domain (unknown origin)	B	7.52	pIC50	30	nM	IC50	J Med Chem (2013) 56: 7788-7803 [PMID:24093940]
ChEMBL	Inhibition of GST-tagged full length XIAP (unknown origin) assessed as caspase 3/7 reactivation in S-100 cell extract after 4 hrs by fluorescence assay	B	6.55	pEC50	283	nM	EC50	J Med Chem (2013) 56: 7772-7787 [PMID:24083782]
ChEMBL	Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by immunoprecipitation assay	B	7.46	pEC50	35	nM	EC50	J Med Chem (2017) 60: 4611-4625 [PMID:28492317]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]