ChEMBL ligand: CHEMBL213490 ((1-Hydroxy-1-Phosphono-2-[1,1';3',1'']Terphenyl-3-Yl-Ethyl)-Phosphonic Acid)
Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051]
ChEMBL	Binding affinity to Saccharomyces cerevisiae GGPPS	B	7.52	pKi	30	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL	Inhibition of Saccharomyces cerevisiae GGPPS	B	7.15	pIC50	70	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
GtoPdb	-	-	7.22	pKi	60	nM	Ki	Proc Natl Acad Sci USA (2007) 104: 10022-7 [PMID:17535895]
ChEMBL	Binding affinity to human GGPPS	B	7.22	pKi	60	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	5.67	pIC50	2140	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL	Inhibition of human GGPPS	B	5.68	pIC50	2100	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	5.7	pIC50	1995.26	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]