ChEMBL ligand: CHEMBL24773
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
regulator of G-protein signaling 4/Regulator of G-protein signaling 4 in Human [ChEMBL: CHEMBL1795091] [GtoPdb: 2811] [UniProtKB: P49798] There should be some charts here, you may need to enable JavaScript!
regulator of G-protein signaling 8/Regulator of G-protein signaling 8 in Human [ChEMBL: CHEMBL2034803] [GtoPdb: 2813] [UniProtKB: P57771] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta	B	4.15	pIC50	70000	nM	IC50	J Med Chem (2002) 45: 1292-1299 [PMID:11881998]
ChEMBL	Inhibition of GSK3beta	B	4.15	pIC50	70000	nM	IC50	ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763]
regulator of G-protein signaling 4/Regulator of G-protein signaling 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795091] [GtoPdb: 2811] [UniProtKB: P49798]
GtoPdb	Inhibition of Gαo binding	-	7.84	pIC50	14.4	nM	IC50	ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763]
ChEMBL	Inhibition of RGS4 interaction with Galpha0 protein by flow cytometry protein interaction assay	B	7.84	pIC50	14.4	nM	IC50	ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763]
regulator of G-protein signaling 8/Regulator of G-protein signaling 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034803] [GtoPdb: 2813] [UniProtKB: P57771]
ChEMBL	Inhibition of RGS8 interaction with Galpha0 protein by flow cytometry protein interaction assay	B	4.08	pIC50	83500	nM	IC50	ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763]
GtoPdb	Inhibition of Gαo binding	-	4.08	pIC50	83500	nM	IC50	ACS Med Chem Lett (2012) 3: 146-150 [PMID:22368763]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]