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ChEMBL ligand: CHEMBL511410 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0] | ||||||||
ChEMBL | Inhibition of CK1-gamma1 | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
GtoPdb | - | - | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658] |
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
ChEMBL | Inhibition of IKKalpha | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of human recombinant MK2 | B | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
GtoPdb | - | - | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5.38 | pIC50 | 4200 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of p38alpha | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
ChEMBL | Inhibition of PDGFRalpha | B | 4.95 | pIC50 | 11100 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Inhibition of PKCalpha | B | 4.47 | pIC50 | 33600 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658] |
ChEMBL | Inhibition of ROCK1 | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] | ||||||||
ChEMBL | Inhibition of RSK1 | B | 6.54 | pIC50 | 290 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
GtoPdb | - | - | 6.54 | pIC50 | 290 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of Aurora B | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibition of FYN | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of SRC | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658] |
protein kinase A in Human [GtoPdb: 1694] | ||||||||
GtoPdb | - | - | 6.57 | pIC50 | 270 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658] |
checkpoint kinase 1 in Human [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
GtoPdb | - | - | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]