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ChEMBL ligand: CHEMBL1215304 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
ChEMBL | Inhibition of JNK3 | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2010) 53: 5727-5737 [PMID:20684608] |
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2010) 53: 5727-37 [PMID:20684608] |
ChEMBL | Inhibition of ROCK1 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2010) 53: 5727-5737 [PMID:20684608] |
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
ChEMBL | Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay | B | 7.29 | pIC50 | 51 | nM | IC50 | J Med Chem (2010) 53: 5727-5737 [PMID:20684608] |
GtoPdb | - | - | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2010) 53: 5727-37 [PMID:20684608] |
ChEMBL | Inhibition of ROCK2 | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2010) 53: 5727-5737 [PMID:20684608] |
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25] | ||||||||
ChEMBL | Inhibition of MRCKalpha | B | 6.17 | pIC50 | 669 | nM | IC50 | J Med Chem (2010) 53: 5727-5737 [PMID:20684608] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]