ChEMBL ligand: CHEMBL1215304
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] There should be some charts here, you may need to enable JavaScript!
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL	Inhibition of JNK3	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2010) 53: 5727-5737 [PMID:20684608]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
GtoPdb	-	-	8	pIC50	10	nM	IC50	J Med Chem (2010) 53: 5727-37 [PMID:20684608]
ChEMBL	Inhibition of ROCK1	B	8	pIC50	10	nM	IC50	J Med Chem (2010) 53: 5727-5737 [PMID:20684608]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL	Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay	B	7.29	pIC50	51	nM	IC50	J Med Chem (2010) 53: 5727-5737 [PMID:20684608]
GtoPdb	-	-	9	pIC50	<1	nM	IC50	J Med Chem (2010) 53: 5727-37 [PMID:20684608]
ChEMBL	Inhibition of ROCK2	B	9	pIC50	<1	nM	IC50	J Med Chem (2010) 53: 5727-5737 [PMID:20684608]
ChEMBL	Inhibition of ROCK2 (unknown origin)	B	9	pIC50	<1	nM	IC50	Eur J Med Chem (2021) 225: 113742-113742 [PMID:34388381]
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
ChEMBL	Inhibition of MRCKalpha	B	6.17	pIC50	669	nM	IC50	J Med Chem (2010) 53: 5727-5737 [PMID:20684608]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]