compound 77 [PMID: 24793884] [Ligand Id: 8217] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3261517 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| ChEMBL | Inhibition of CK1alpha (unknown origin) by TR-FRET assay | B | 6.26 | pIC50 | 545 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| ChEMBL | Inhibition of CK1delta (unknown origin) by TR-FRET assay | B | 6.98 | pIC50 | 104 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
| ChEMBL | Inhibition of CK2 (unknown origin) by homogeneous time-resolved fluorescence assay | B | 4.19 | pIC50 | 65000 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311, Q9UBU7] | ||||||||
| ChEMBL | Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs | B | 6.06 | pIC50 | 862 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay | B | 8.17 | pIC50 | 6.81 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| GtoPdb | - | - | 8.17 | pIC50 | 6.81 | nM | IC50 | Eur J Med Chem (2014) 80: 364-82 [PMID:24793884] |
| cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
| ChEMBL | Inhibition of CDK9/Cyclin-T1 (unknown origin) by homogeneous time-resolved fluorescence assay | B | 6.14 | pIC50 | 729 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of CDK1/Cyclin-B (unknown origin) by homogeneous time-resolved fluorescence assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] | ||||||||
| ChEMBL | Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay | B | 4.97 | pIC50 | 10600 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
| ChEMBL | Inhibition of CDK4/Cyclin-D1 (unknown origin) by homogeneous time-resolved fluorescence assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| ChEMBL | Inhibition of Pim1 (unknown origin) by homogeneous time-resolved fluorescence assay | B | 6 | pIC50 | >1000 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
