plevitrexed [Ligand Id: 8278] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL126648 (Bgc-9331, NSC-696259, Plevitrexed, ZD-9331, ZD9331) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| thymidylate synthetase/Thymidylate synthase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607] | ||||||||
| GtoPdb | Measured using partially purified thymidylate synthase from mouse L1210 leukemia cells. | - | 9.36 | pKi | 0.44 | nM | Ki | J Med Chem (1999) 42: 3809-20 [PMID:10508430] |
| ChEMBL | Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | B | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (1999) 42: 3809-3820 [PMID:10508430] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
