mercaptoacrylate inhibitor of calpain 1 [Ligand Id: 8570] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3221938
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  • calpain 1 in Pig [GtoPdb: 2336]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Calpain 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4062] [UniProtKB: P35750]
ChEMBL Inhibition of Ca2+-dependent activation of porcine calpain-1 using SucLY-AMC as substrate B 7.7 pIC50 20 nM IC50 Medchemcomm (2012) 3: 566-570
ChEMBL Inhibition of Ca2+-dependent activation of porcine calpain-1 using H-K(FAM)-EVYGMMK(DABCYL)-OH as substrate by FRET assay B 8.22 pIC50 6 nM IC50 Medchemcomm (2012) 3: 566-570
calpain 1 in Pig [GtoPdb: 2336]
GtoPdb - - 8.22 pIC50 6 nM IC50 Medchemcomm (2012) 3: 566

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]