3S,4R-293B [Ligand Id: 8610] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL44297 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv7.1/Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221347] [GtoPdb: 560] [UniProtKB: P15382, P51787] | ||||||||
| ChEMBL | Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1) | B | 4.35 | pIC50 | 44500 | nM | IC50 | J Med Chem (2001) 44: 3831-3837 [PMID:11689069] |
| GtoPdb | - | - | 4.52 | pIC50 | 30100 | nM | IC50 | Br J Pharmacol (2001) 134: 1647-54 [PMID:11739240] |
| ChEMBL | Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 2) | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2001) 44: 3831-3837 [PMID:11689069] |
| Kv4.3/Voltage-gated potassium channel subunit Kv4.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1964] [GtoPdb: 554] [UniProtKB: Q9UK17] | ||||||||
| ChEMBL | The inhibitory concentration for 50% was measured on potassium channel complex | F | 5.85 | pIC50 | 1400 | nM | IC50 | J Med Chem (2001) 44: 1627-1653 [PMID:11356099] |
| Voltage-gated potassium channel subunit Kv7.1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5135] [UniProtKB: O70344] | ||||||||
| ChEMBL | Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes | B | 4.41 | pIC50 | 39000 | nM | IC50 | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| ChEMBL | Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes | F | 5.21 | pIC50 | 6200 | nM | IC50 | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
