compound 3b [PMID: 24946214] [Ligand Id: 8618] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3287940 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| proteasome 20S subunit beta 1/Proteasome component C5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4208] [GtoPdb: 2404] [UniProtKB: P20618] | ||||||||
| ChEMBL | Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay | B | 6.62 | pKi | 240 | nM | Ki | Eur J Med Chem (2014) 83: 1-14 [PMID:24946214] |
| GtoPdb | - | - | 6.62 | pKi | 240 | nM | Ki | Eur J Med Chem (2014) 83: 1-14 [PMID:24946214] |
| proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| ChEMBL | Inhibition of chymotrypsin-like activity of 20S proteasome in human erythrocytes using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay | B | 7.29 | pKi | 51 | nM | Ki | Eur J Med Chem (2014) 83: 1-14 [PMID:24946214] |
| proteasome 20S subunit beta 5 in Bovine [GtoPdb: 2406] | ||||||||
| GtoPdb | Inhibition of chymotrypsin-like activity. | - | 8.29 | pKi | 5.1 | nM | Ki | Eur J Med Chem (2014) 83: 1-14 [PMID:24946214] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
