casp 4 inhib [Ligand Id: 8635] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL293622 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] | ||||||||
| ChEMBL | Inhibitory activity against caspase-1 | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| Caspase 2/Caspase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4884] [GtoPdb: 1618] [UniProtKB: P42575] | ||||||||
| ChEMBL | Inhibitory activity against caspase-2 | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] | ||||||||
| ChEMBL | Inhibitory activity against caspase-3 | B | 6.3 | pKi | 500 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| ChEMBL | Inhibition of recombinant human caspase-3 | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| Caspase 4/Caspase-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2226] [GtoPdb: 1620] [UniProtKB: P49662] | ||||||||
| ChEMBL | Inhibitory activity against caspase-4 | B | 5.4 | pKi | 4000 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| GtoPdb | - | - | 5.4 | pKi | 4000 | nM | Ki | J Med Chem (2001) 44: 2015-26 [PMID:11384246] |
| Caspase 6/Caspase-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308] [GtoPdb: 1622] [UniProtKB: P55212] | ||||||||
| ChEMBL | Inhibitory activity against Caspase-6 | B | 5.77 | pKi | 1700 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| Caspase 7/Caspase-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210] | ||||||||
| ChEMBL | Inhibitory activity against Caspase-7 | B | 6.54 | pKi | 290 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790] | ||||||||
| ChEMBL | Inhibitory activity against Caspase-8 | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| Caspase 9/Caspase-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2273] [GtoPdb: 1625] [UniProtKB: P55211] | ||||||||
| ChEMBL | Inhibitory activity against Caspase-9 | B | 5.14 | pKi | 7200 | nM | Ki | J Med Chem (2001) 44: 2015-2026 [PMID:11384246] |
| Human rhinovirus A protease in Human rhinovirus sp. (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2857] [UniProtKB: Q4U254] | ||||||||
| ChEMBL | Inhibition of human rhinovirus 3C protease | B | 5.01 | pKi | 9700 | nM | Ki | J Med Chem (1996) 39: 5072-5082 [PMID:8978838] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
