evofosfamide [Ligand Id: 8695] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL260046 (Evofosfamide, HAP-302, TH-302) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Alpha enolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3298] [UniProtKB: P06733] | ||||||||
| ChEMBL | Inhibition of ENO1 in wild-type human LN319 cells incubated for 5 days in presence of 21 % oxygen by crystal violet staining based spectrophotometry | B | 5.32 | pIC50 | 4838 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1484-1489 [PMID:32676158] |
| ChEMBL | Inhibition of ENO1 in overexpressed human D423 cells incubated for 5 days in presence of 21 % oxygen by crystal violet staining based spectrophotometry | B | 5.59 | pIC50 | 2554 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1484-1489 [PMID:32676158] |
| ChEMBL | Inhibition of ENO1 in wild-type human LN319 cells incubated for 5 days in presence of 1 % oxygen by crystal violet staining based spectrophotometry | B | 6.05 | pIC50 | 897 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1484-1489 [PMID:32676158] |
| ChEMBL | Inhibition of ENO1 in overexpressed human D423 cells incubated for 5 days in presence of 1 % oxygen by crystal violet staining based spectrophotometry | B | 6.52 | pIC50 | 301 | nM | IC50 | ACS Med Chem Lett (2020) 11: 1484-1489 [PMID:32676158] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
