compound 12e [PMID: 18605714] [Ligand Id: 8787] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL515637
  • sPLA2-2D/Group IID secretory phospholipase A2 in Human [ChEMBL: CHEMBL4281] [GtoPdb: 1418] [UniProtKB: Q9UNK4]
  • sPLA2-2D/Group IID secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL5537] [GtoPdb: 1418] [UniProtKB: Q9WVF6]
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  • sPLA2-2E/Group IIE secretory phospholipase A2 in Human [ChEMBL: CHEMBL2154] [GtoPdb: 1419] [UniProtKB: Q9NZK7]
  • sPLA2-2E/Group IIE secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL4201] [GtoPdb: 1419] [UniProtKB: Q9QUL3]
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  • sPLA2-2F/Group IIF secretory phospholipase A2 in Human [ChEMBL: CHEMBL4278] [GtoPdb: 1420] [UniProtKB: Q9BZM2]
  • sPLA2-2F/Group IIF secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL5361] [GtoPdb: 1420] [UniProtKB: Q9QZT4]
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  • sPLA2-10/Group X secretory phospholipase A2 in Human [ChEMBL: CHEMBL4342] [GtoPdb: 1422] [UniProtKB: O15496]
  • sPLA2-10/Group X secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL4200] [GtoPdb: 1422] [UniProtKB: Q9QXX3]
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  • sPLA2-1B/Phospholipase A2 group 1B in Human [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054]
  • sPLA2-1B/Phospholipase A2 group 1B in Mouse [ChEMBL: CHEMBL4378] [GtoPdb: 1416] [UniProtKB: Q9Z0Y2]
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  • sPLA2-2A/Phospholipase A2 group IIA in Human [ChEMBL: CHEMBL3474] [GtoPdb: 1417] [UniProtKB: P14555]
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  • sPLA2-2A in Human [GtoPdb: 1417] [UniProtKB: P14555]
  • sPLA2-2A/Phospholipase A2, membrane associated in Mouse [ChEMBL: CHEMBL5761] [GtoPdb: 1417] [UniProtKB: P31482]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
sPLA2-2D/Group IID secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4281] [GtoPdb: 1418] [UniProtKB: Q9UNK4]
GtoPdb - - 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
ChEMBL Inhibition of human group2D phospholipase A2 by [3H]oleic acid-labeled Escherichia coli membrane assay B 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2D/Group IID secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5537] [GtoPdb: 1418] [UniProtKB: Q9WVF6]
ChEMBL Inhibition of mouse group2D phospholipase A2 fluorimetric assay B 6.49 pIC50 320 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2E/Group IIE secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2154] [GtoPdb: 1419] [UniProtKB: Q9NZK7]
GtoPdb - - 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
ChEMBL Inhibition of human group2E phospholipase A2 fluorimetric assay B 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2E/Group IIE secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4201] [GtoPdb: 1419] [UniProtKB: Q9QUL3]
ChEMBL Inhibition of mouse group2E phospholipase A2 fluorimetric assay B 7.74 pIC50 18 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2F/Group IIF secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4278] [GtoPdb: 1420] [UniProtKB: Q9BZM2]
GtoPdb - - 7.3 pIC50 50 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
ChEMBL Inhibition of human group2F phospholipase A2 fluorimetric assay B 7.3 pIC50 50 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2F/Group IIF secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5361] [GtoPdb: 1420] [UniProtKB: Q9QZT4]
ChEMBL Inhibition of mouse group2F phospholipase A2 fluorimetric assay B 6.77 pIC50 170 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-10/Group X secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4342] [GtoPdb: 1422] [UniProtKB: O15496]
ChEMBL Inhibition of human group2X phospholipase A2 fluorimetric assay B 7.7 pIC50 20 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.7 pIC50 20 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
sPLA2-10/Group X secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4200] [GtoPdb: 1422] [UniProtKB: Q9QXX3]
ChEMBL Inhibition of mouse group2X phospholipase A2 fluorimetric assay B 8.22 pIC50 6 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-1B/Phospholipase A2 group 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054]
ChEMBL Inhibition of human group1B phospholipase A2 fluorimetric assay B 7.08 pIC50 84 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.08 pIC50 84 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
sPLA2-1B/Phospholipase A2 group 1B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4378] [GtoPdb: 1416] [UniProtKB: Q9Z0Y2]
ChEMBL Inhibition of mouse group1B phospholipase A2 fluorimetric assay B 6.8 pIC50 160 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2A/Phospholipase A2 group IIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3474] [GtoPdb: 1417] [UniProtKB: P14555]
ChEMBL Inhibition of human group2A phospholipase A2 fluorimetric assay B 7.4 pIC50 40 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.4 pIC50 40 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
PLA2-G5/Phospholipase A2 group V in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4323] [GtoPdb: 1430] [UniProtKB: P39877]
ChEMBL Inhibition of human group2V phospholipase A2 fluorimetric assay B 7.46 pIC50 35 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.46 pIC50 35 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
PLA2-G5/Phospholipase A2 group V in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4167] [GtoPdb: 1430] [UniProtKB: P97391]
ChEMBL Inhibition of mouse group2V phospholipase A2 fluorimetric assay B 7.7 pIC50 20 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2A in Human [GtoPdb: 1417] [UniProtKB: P14555]
GtoPdb - - 7.4 pIC50 40 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
sPLA2-2A/Phospholipase A2, membrane associated in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5761] [GtoPdb: 1417] [UniProtKB: P31482]
ChEMBL Inhibition of mouse group2A phospholipase A2 fluorimetric assay B 7.52 pIC50 30 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]