ChEMBL ligand: CHEMBL481422 (SM-122)
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09] There should be some charts here, you may need to enable JavaScript!
Genome polyprotein in Zika virus [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9] There should be some charts here, you may need to enable JavaScript!
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
ChEMBL	Binding affinity to human cIAP1 BIR2-BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay	B	7.74	pKi	18	nM	Ki	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Binding affinity to human cIAP1 BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay	B	8.17	pKi	6.8	nM	Ki	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	8.17	pKi	6.7	nM	Ki	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL	Binding affinity to BIR3 domain of cIAP1 by fluorescence polarization assay	B	8.17	pKi	6.7	nM	Ki	J Med Chem (2012) 55: 106-114 [PMID:22148838]
GtoPdb	-	-	9	pKi	1	nM	Ki	J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL	Displacement of fluorescently tagged SM5F from human cIAP-1 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay	B	9	pKi	1	nM	Ki	J Med Chem (2008) 51: 8158-8162 [PMID:19049347]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2009) 52: 593-596 [PMID:19138149]
ChEMBL	Competitive inhibition of human cIAP1BIR2-BIR3 domain after 2 to 3 hrs by fluorescence polarization assay	B	7.22	pIC50	60	nM	IC50	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	7.34	pIC50	46.2	nM	IC50	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL	Binding affinity to BIR3 domain of cIAP1 by fluorescence polarization assay	B	7.34	pIC50	46.2	nM	IC50	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Competitive inhibition of human cIAP1 BIR3 domain after 2 to 3 hrs by fluorescence polarization assay	B	7.42	pIC50	38	nM	IC50	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	7.74	pKi	18.3	nM	Ki	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL	Binding affinity to BIR3 domain of cIAP2 by fluorescence polarization assay	B	7.74	pKi	18.3	nM	Ki	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Binding affinity to human cIAP2 BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay	B	7.74	pKi	18	nM	Ki	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	8.74	pKi	1.84	nM	Ki	J Med Chem (2009) 52: 593-596 [PMID:19138149]
GtoPdb	-	-	8.74	pKi	1.8	nM	Ki	J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	7.13	pIC50	74.7	nM	IC50	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL	Binding affinity to BIR3 domain of cIAP2 by fluorescence polarization assay	B	7.13	pIC50	74.7	nM	IC50	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Competitive inhibition of human cIAP2 BIR3 domain after 2 to 3 hrs by fluorescence polarization assay	B	7.15	pIC50	70	nM	IC50	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09]
ChEMBL	Displacement of fluorescently tagged SM5F from human cIAP-2 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay	B	8.74	pKi	1.8	nM	Ki	J Med Chem (2008) 51: 8158-8162 [PMID:19049347]
Genome polyprotein in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9]
ChEMBL	Inhibition of Zika virus NS2B-NS3 protease	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126965-126965 [PMID:31980339]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL	Binding affinity to XIAP-BIR3 domain (unknown origin)	B	7.59	pKd	26	nM	Kd	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Binding affinity to BIR2 domain of XIAP by fluorescence polarization assay	B	5.09	pKi	8200	nM	Ki	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	6.39	pKi	408	nM	Ki	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay	B	6.39	pKi	408	nM	Ki	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay	B	6.61	pKi	248	nM	Ki	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay	B	6.72	pKi	191	nM	Ki	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	6.72	pKi	190.7	nM	Ki	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	7.59	pKi	26	nM	Ki	J Med Chem (2009) 52: 593-596 [PMID:19138149]
ChEMBL	Binding affinity to N-terminal 6xHis-tagged human cloned XIAP BIR3 domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization-based competitive binding assay	B	7.59	pKi	26	nM	Ki	J Med Chem (2008) 51: 7169-7180 [PMID:18954041]
GtoPdb	-	-	7.59	pKi	26	nM	Ki	J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL	Binding affinity to BIR2 domain of XIAP by fluorescence polarization assay	B	4.72	pIC50	18900	nM	IC50	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Binding affinity to XIAP-BIR2 domain (unknown origin)	B	5.25	pIC50	5600	nM	IC50	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	5.91	pIC50	1240	nM	IC50	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay	B	5.91	pIC50	1240	nM	IC50	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay	B	6.09	pIC50	819	nM	IC50	J Med Chem (2011) 54: 3306-3318 [PMID:21462933]
ChEMBL	Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay	B	6.2	pIC50	636	nM	IC50	J Med Chem (2012) 55: 106-114 [PMID:22148838]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	6.2	pIC50	635.7	nM	IC50	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL	Binding affinity to XIAP-BIR2/BIR3 domain (unknown origin)	B	6.36	pIC50	438	nM	IC50	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Inhibition of of XIAP-BIR2/BIR3 domain (unknown origin)	B	6.36	pIC50	438	nM	IC50	J Med Chem (2019) 62: 5750-5772 [PMID:30676015]
ChEMBL	Antagonist activity at human recombinant XIAP BIR3 protein assessed as restoration of caspase 9 activity after 60 mins	F	6.2	pEC50	630	nM	EC50	J Med Chem (2008) 51: 7169-7180 [PMID:18954041]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]