TAK-637 [Ligand Id: 9329] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL339486 (TAK-637) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| ChEMBL | Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells) | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1999) 42: 3982-3993 [PMID:10508446] |
| ChEMBL | Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells) | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1999) 42: 3982-3993 [PMID:10508446] |
| ChEMBL | Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting | B | 9.35 | pIC50 | 0.45 | nM | IC50 | Bioorg Med Chem (2011) 19: 5175-5182 [PMID:21807525] |
| GtoPdb | Inhibition of [125I]BH-SP binding in human IM-9 cells. | - | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1999) 42: 3982-93 [PMID:10508446] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
