ChEMBL ligand: CHEMBL188381 (GW806742X)
mixed lineage kinase domain like pseudokinase/Mixed lineage kinase domain-like protein in Human [ChEMBL: CHEMBL1938217] [GtoPdb: 2106] [UniProtKB: Q8NB16] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mixed lineage kinase domain like pseudokinase/Mixed lineage kinase domain-like protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938217] [GtoPdb: 2106] [UniProtKB: Q8NB16]
GtoPdb	Surface plasmon resonance (SPR) assay.	-	5.03	pKd	9300	nM	Kd	Proc Natl Acad Sci USA (2014) 111: 15072-7 [PMID:25288762]
ChEMBL	Binding affinity to MLKL (unknown origin)	B	5.03	pKd	9300	nM	Kd	J Med Chem (2020) 63: 1490-1510 [PMID:31622096]
GtoPdb	Inhibition of TSQ-induced necroptosis in cellular assays.	-	7	pIC50	100	nM	IC50	Proc Natl Acad Sci USA (2014) 111: 15072-7 [PMID:25288762]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Further kinetic evaluation of compounds supplied by Sanofi against AuroraA within a BIAcore3000 instrument	B	4.9	pKd	12461.05	nM	Kd	K4DD drug target binding kinetics data
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibitory concentration against human VEGFR2 kinase	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3519-3523 [PMID:15990302]
GtoPdb	-	-	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3519-23 [PMID:15990302]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]