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ChEMBL ligand: CHEMBL1190711 (BAY-613606) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Inhibition of SYK | B | 8.12 | pKi | 7.5 | nM | Ki | J Med Chem (2012) 55: 3614-3643 [PMID:22257213] |
GtoPdb | - | - | 7.59 | pIC50 | 25.5 | nM | IC50 | PLoS ONE (2012) 7: e41343 [PMID:22815993] |
ChEMBL | Inhibition of SYK in human Ramos B cells assessed as reduction in Ca2+ release | B | 7.09 | pEC50 | 81 | nM | EC50 | J Med Chem (2012) 55: 3614-3643 [PMID:22257213] |
ChEMBL | Inhibition of SYK in human U937 cells assessed as reduction FcgammaR-mediated superoxide production | B | 7.28 | pEC50 | 52 | nM | EC50 | J Med Chem (2012) 55: 3614-3643 [PMID:22257213] |
ChEMBL | Inhibition of SYK in peripheral blood monocytes assessed as reduction FcgammaR-mediated superoxide production | B | 7.92 | pEC50 | 12 | nM | EC50 | J Med Chem (2012) 55: 3614-3643 [PMID:22257213] |
component of inhibitor of nuclear factor kappa B kinase complex in Human [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
GtoPdb | - | - | 7.35 | pKi | 45 | nM | Ki | PLoS ONE (2016) 11: e0150339 [PMID:26930276] |
mitogen-activated protein kinase kinase kinase kinase 2 in Human [GtoPdb: 2086] [UniProtKB: Q12851] | ||||||||
GtoPdb | - | - | 7.95 | pIC50 | 11.3 | nM | IC50 | PLoS ONE (2012) 7: e41343 [PMID:22815993] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]