WAY-316606 [Ligand Id: 9945] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL495575 (WAY-316606) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Proto-oncogene protein Wnt-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6079] [UniProtKB: P56703] | ||||||||
| ChEMBL | Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay | F | 6.19 | pEC50 | 650 | nM | EC50 | J Med Chem (2009) 52: 105-116 [PMID:19072540] |
| Secreted frizzled-related protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5517] [UniProtKB: Q8N474] | ||||||||
| ChEMBL | Binding affinity to human purified SARP2 by fluorescent polarization assay | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2009) 52: 105-116 [PMID:19072540] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
