tomivosertib

Ligand id: 10167

Name: tomivosertib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 114.93
Molecular weight 340.16
XLogP 2.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
International Nonproprietary Names
INN number INN
10727 tomivosertib
Synonyms
compound 23 [PMID: 29526098] | eFT-508 | eFT508
Comments
Tomivosertib (eFT508) is an orally active and selective mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) inhibitor that is being developed by eFFECTOR Therapeutics for anti-neoplastic potential [2].
Database Links
GtoPdb PubChem SID 381118877
PubChem CID 118598754
RCSB PDB Ligand N45
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Search UniChem for chemical match using the InChIKey HKTBYUWLRDZAJK-UHFFFAOYSA-N
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SynPHARM 85807 (in complex with MAP kinase interacting serine/threonine kinase 2)