Synonyms: 24-exo [2]
Compound class:
Synthetic organic
Comment: RJW100 is a small-molecule synthetic agonist of the orphan nuclear receptors, liver receptor homolog 1 (hLRH-1; NR5A2) and steroidogenic factor-1 (SF-1; NR5A1) [2]. It has good solubility and stability and is suitable as an experimental tool compound.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Mays SG, Flynn AR, Cornelison JL, Okafor CD, Wang H, Wang G, Huang X, Donaldson HN, Millings EJ, Polavarapu R et al.. (2019)
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem, 62 (24): 11022-11034. [PMID:31419141] |
2. Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ et al.. (2011)
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem, 54 (7): 2266-81. [PMID:21391689] |