IRL752   Click here for help

GtoPdb Ligand ID: 11098

Synonyms: IRL 752 | IRL-752
Compound class: Synthetic organic
Comment: Effector studies show that IRL752 acts an antagonist at 5-hydroxytryptamine-7 receptor (serotonin-7, 5-HT7R) and cortical alpha receptor (alpha-2CR) [1]. Being developed for the treatment of impaired balance (postural dysfunction) and falls in Parkinson's disease [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 21.26
Molecular weight 213.1
XLogP 1.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CO[C@]1(CNCC1)c1cccc(c1F)F
Isomeric SMILES CO[C@]1(CNCC1)c1cccc(c1F)F
InChI InChI=1S/C11H13F2NO/c1-15-11(5-6-14-7-11)8-3-2-4-9(12)10(8)13/h2-4,14H,5-7H2,1H3/t11-/m1/s1
InChI Key LJNFYMMXCXGFCP-LLVKDONJSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine
Synonyms Click here for help
IRL 752 | IRL-752
Database Links Click here for help
GtoPdb PubChem SID 434122159
PubChem CID 135381565
Search Google for chemical match using the InChIKey LJNFYMMXCXGFCP-LLVKDONJSA-N
Search Google for chemicals with the same backbone LJNFYMMXCXGFCP
UniChem Compound Search for chemical match using the InChIKey LJNFYMMXCXGFCP-LLVKDONJSA-N
UniChem Connectivity Search for chemical match using the InChIKey LJNFYMMXCXGFCP-LLVKDONJSA-N