Synonyms: CM-082 | CM082 | Example 8 [WO2008033562A2] | EYP-1901 | X-82
Compound class:
Synthetic organic
Comment: Vorolanib (CM082) is a potent and selective, oral clinical stage multi-kinase inhibitor. Targets include all VEGFR isoforms, PDGFR and CSF1R. [1-3]. It is a structural derivative of sunitinib. Vorolanib has anti-angiogenic activity, and is being investigated for anti-tumour effects and utility to treat ocular neovascularisation.
|
|
Classification | |
Compound class | Synthetic organic |
IUPAC Name |
N-[(3S)-1-(dimethylcarbamoyl)pyrrolidin-3-yl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
International Nonproprietary Names | |
INN number | INN |
10338 | vorolanib |
Synonyms |
CM-082 | CM082 | Example 8 [WO2008033562A2] | EYP-1901 | X-82 |
Database Links | |
CAS Registry No. | 1013920-15-4 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL4297587 |
DrugBank Ligand | DB15247 |
GtoPdb PubChem SID | 442878652 |
PubChem CID | 59215954 |
Search Google for chemical match using the InChIKey | KMIOJWCYOHBUJS-HAKPAVFJSA-N |
Search Google for chemicals with the same backbone | KMIOJWCYOHBUJS |
Search PubMed clinical trials | vorolanib |
Search PubMed titles | vorolanib |
Search PubMed titles/abstracts | vorolanib |
UniChem Compound Search for chemical match using the InChIKey | KMIOJWCYOHBUJS-HAKPAVFJSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KMIOJWCYOHBUJS-HAKPAVFJSA-N |