Synonyms: compound 41 [PMID: 34550687] | FRM024
Compound class:
Synthetic organic
Comment: FRM-024 is a CNS-penetrating γ secretase modulator that was developed for its capacity to improve amyloid processing and potential as an Alzheimer's disease therapeutic [1]. Gamma secretase modulators reduce the levels of the toxic longer amyloid β (Aβ) chains (Aβ42, Aβ43) that accummulate in Alzheimer's brains. They do not alter total Aβ levels. In particular, such modulators may afford potential for clinical intervention in patients with inherited loss-of-function mutations in presenilin genes which increase production of the toxic forms of Aβ.
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(5S,6R)-5-(4-chlorophenyl)-6-cyclopropyl-3-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-5,6-dihydro-2H-1,2,4-oxadiazine |
Synonyms |
compound 41 [PMID: 34550687] | FRM024 |
Database Links | |
GtoPdb PubChem SID | 458923787 |
PubChem CID | 126599754 |
Search Google for chemical match using the InChIKey | IOQORVDNYPOZPL-VQTJNVASSA-N |
Search Google for chemicals with the same backbone | IOQORVDNYPOZPL |
UniChem Compound Search for chemical match using the InChIKey | IOQORVDNYPOZPL-VQTJNVASSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | IOQORVDNYPOZPL-VQTJNVASSA-N |