Synonyms: compound 4c [PMID: 34614283] | PG PROTAC 4c
Compound class:
Synthetic organic
Comment: SJ995973 is a novel proteolysis-targeting chimera (PROTAC) molecule that targets bromodomain and extra-terminal (BET) proteins for proteasome-mediated degradation [1]. The cereblon binding warhead contains a phenyl glutarimide group that improves chemical resistance to hydrolysis, thereby improving PROTAC efficacy. The BET binding component is based on the BRD4 inhibitor (+)-JQ1, that is also utilised in the PROTAC dBET6.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Molecular structure representations generated using Open Babel