Compound class:
Synthetic organic
Comment: This compound is reported as an inhibitor of kinesin family member 18A (KIF18A; Q8NI77) [1]. Compound 24 binds at the interface of KIF18A and tubulin. KIF18A is a molecular target for the development of therapeutics for chromosomally unstable cancers. Inhibiting KIF18A function drives mitotic arrest and cell death. Compound 24 shares some structural similarity with the clinical stage KIF18A inhibitor AMG650.
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-(6-azaspiro[2.5]octan-6-yl)-N-[3-(tert-butylsulfamoyl)phenyl]-4-[(1-methylcyclopropyl)sulfonylamino]benzamide |
Database Links | |
GtoPdb PubChem SID | 464244146 |
PubChem CID | 155780813 |
Search Google for chemical match using the InChIKey | MZGYQJDGUVDYIK-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | MZGYQJDGUVDYIK |
UniChem Compound Search for chemical match using the InChIKey | MZGYQJDGUVDYIK-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MZGYQJDGUVDYIK-UHFFFAOYSA-N |