Compound class:
Synthetic organic
Comment: This is one of the compounds that are claimed as PDE4B inhibitors in Boehringer Ingelheim's patent WO2013026797A1 [2]. The compounds are claimed for potential to treat inflammatory or allergic diseases of the respiratory tract, such as COPD or asthma. Boehringer Ingelheim's oral PED4B clinical lead BI 1015550 has entered clinical studies [1,3], but as no structure has been disclosed, it is not clear if BI 1015550 is one of the examples in WO2013026797A1.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Molecular structure representations generated using Open Babel