RMC-5552   Click here for help

GtoPdb Ligand ID: 12338

Synonyms: compound 38 [PMID: 36533617] | RMC5552
Compound class: Synthetic organic
Comment: RMC-5552 is a selective bi-steric inhibitor of mTORC1 [1]. Mechanistically it interacts with both the orthosteric and allosteric binding sites of mTOR, and inhibits phosphorylation of S6K and 4EBP1 (to provide anti-tumour activity) whilst sparing mTORC2-mediated effects on AKT signalling and glucose metabolism. It was developed for potential to treat mTORC1-activated tumours, and is an active clinical lead (Jan 2023).
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 32
Hydrogen bond donors 6
Rotatable bonds 40
Topological polar surface area 432.51
Molecular weight 1776.97
XLogP 5.21
No. Lipinski's rules broken 4
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CO[C@@H]1C[C@@H](CC[C@H]1OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N1CCc2c(C1)ccc(c2)Cn1nc(c2c1ncnc2N)c1ccc2c(c1)nc(o2)N)C[C@H]([C@@H]1C[C@@H](O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C(/[C@H](C[C@H]2O[C@](C(=O)C(=O)N3[C@H](C(=O)O1)CCCC3)(O)[C@H](C)CC2)OC)\C)C
Isomeric SMILES [C@@H]12CCCCN1C(=O)C(=O)[C@]1([C@@H](CC[C@@H](C[C@H](OC)/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H]([C@@H](C[C@H](OC2=O)[C@@H](C[C@H]2C[C@H]([C@@H](CC2)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N2CCc3c(ccc(Cn4c5ncnc(N)c5c(n4)c4ccc5c(c4)nc(o5)N)c3)C2)OC)C)O)C)/C)O)OC)C)C)/C)O1)C)O
InChI InChI=1S/C93H136N10O24/c1-59-16-12-11-13-17-60(2)77(113-8)54-71-24-19-65(7)93(112,127-71)86(108)89(109)102-30-15-14-18-73(102)90(110)124-78(55-74(104)61(3)49-64(6)84(107)85(115-10)83(106)63(5)48-59)62(4)50-66-21-25-76(79(52-66)114-9)126-92(111)96-29-33-117-35-37-119-39-41-121-43-45-123-47-46-122-44-42-120-40-38-118-36-34-116-32-28-80(105)101-31-27-68-51-67(20-22-70(68)57-101)56-103-88-81(87(94)97-58-98-88)82(100-103)69-23-26-75-72(53-69)99-91(95)125-75/h11-13,16-17,20,22-23,26,49,51,53,58-59,61-63,65-66,71,73-74,76-79,84-85,104,107,112H,14-15,18-19,21,24-25,27-48,50,52,54-57H2,1-10H3,(H2,95,99)(H,96,111)(H2,94,97,98)/b13-11+,16-12+,60-17+,64-49+/t59-,61-,62-,63-,65-,66+,71+,73+,74-,76-,77+,78+,79-,84-,85+,93-/m1/s1
InChI Key IUTYTXDIGUNPAA-GKVGALOGSA-N
Bioactivity Comments
In cell-based assays RMC-5552 inhibits phosphorylation of S6K, 4EBP1 (downstream targets of the mTORC1 complex) and AKT (a mTORC2 downstream target) with IC50s of 0.14 nM, 0.48 nM and 19 nM respectively [1].