Synonyms: Gantrisin® | NU-445 | sulfafurazole | sulphafurazole
sulfisoxazole is an approved drug (FDA (1948))
Compound class:
Synthetic organic
Comment: Sulfisoxazole (sulfafurazole) is a sulfonamide antibacterial compound [4-5].
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No information available. |
Summary of Clinical Use |
Sulfisoxazole is indicated in the treatment of infections caused by susceptible bacteria, including urinary tract infections, meningococcal meningitis and acute otitis media. Sulfisoxazole has been marketed in a number of jurisdictions, including the US, Canada, Australia, Japan and some European countries. However, there is no information regarding current approval for clinical use of this drug on the US FDA or European Medicines Agency (EMA) websites. Individual national approval agencies may have granted marketing authorisation. Marketed formulations may contain sulfisoxazole acetyl or sulfisoxazole diolamine. Sulfisoxazole is also used in combination with erythromycin or phenazopyridine. |
Mechanism Of Action and Pharmacodynamic Effects |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants [2]. The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis [1]. |