GSK3008348   Click here for help

GtoPdb Ligand ID: 12736

Synonyms: GSK-3008348
Compound class: Synthetic organic
Comment: GSK3008348 is an inhalational inhibitor of integrin αvβ6 that was developed for potential to treat idiopathic pulmonary fibrosis (IPF) [2]. Structurally it is an arginyl-glycinyl-aspartic acid (RGD)-mimetic that replicates the amino acid binding motif of αvβ6 endogenous ligand latency associated peptide-1 (LAP1) [1] that is derived from the N-terminal region of the TGFβ gene product [4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 80.53
Molecular weight 487.64
XLogP 1.97
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC1=NN(C(=C1)C)C2=CC(=CC=C2)[C@H](CC(=O)O)CN3CC[C@@H](CCC4=CC=C5CCCNC5=N4)C3
Isomeric SMILES CC=1C=C(C)N(N1)C2=CC=CC([C@H](CC(O)=O)CN3C[C@@H](CC3)CCC=4C=CC5=C(N4)NCCC5)=C2
InChI InChI=1S/C29H37N5O2/c1-20-15-21(2)34(32-20)27-7-3-5-24(16-27)25(17-28(35)36)19-33-14-12-22(18-33)8-10-26-11-9-23-6-4-13-30-29(23)31-26/h3,5,7,9,11,15-16,22,25H,4,6,8,10,12-14,17-19H2,1-2H3,(H,30,31)(H,35,36)/t22-,25-/m1/s1
InChI Key ZMXBIIQMSGOIRZ-RCZVLFRGSA-N
No information available.
Summary of Clinical Use Click here for help
GSK3008348 was advanced to clinical study to evaluate its safety, tolerability and pharmacokinetic (PK) profile.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02612051 First Time in Human (FTIH) Study of GSK3008348 in Healthy Volunteers and Idiopathic Pulmonary Fibrosis Patients Phase 1 Interventional GlaxoSmithKline 2
NCT03069989 Single Doses of GSK3008348 in Idiopathic Pulmonary Fibrosis (IPF) Participants Using Positron Emission Tomography (PET) Imaging Phase 1 Interventional GlaxoSmithKline This study confirmed target engagement in lung tissue following nebulised dosing with GSK3008348. 3