canlitinib   Click here for help

GtoPdb Ligand ID: 12865

Synonyms: CX-1003 | CX1003 | Kanitinib
Compound class: Synthetic organic
Comment: The structure for canlitinib was obtained from Proposed INN list 129 (August 2023). Therein it is described as a tyrosine kinase inhibitor with antineoplastic activity. It is the primary compound claimed in patent WO2020216188A1, as an AXL protein kinase and/or vascular endothelial growth factor receptor (VEGFR2, KDR) inhibitor [1]. We predict that canlitinib is Beijing Konruns Pharmaceutical's lead candidate CX-1003. CX-1003 may also inhibit hepatocyte growth factor receptor (HGFR/MET).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 16
Topological polar surface area 135.55
Molecular weight 619.61
XLogP 3.34
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COC1=CC2=C(C=C1OCCCCCC(=O)O)N=CC=C2OC3=CC=C(C=C3F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
Isomeric SMILES COC1=CC2=C(C=C1OCCCCCC(O)=O)N=CC=C2OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3F
InChI InChI=1S/C33H31F2N3O7/c1-43-28-18-23-25(19-29(28)44-16-4-2-3-5-30(39)40)36-15-12-26(23)45-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
InChI Key PCKYITPVOLEZKL-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
6-[4-[2-fluoro-4-[[1-[(4-fluorophenyl)carbamoyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxyquinolin-7-yl]oxyhexanoic acid
Synonyms Click here for help
CX-1003 | CX1003 | Kanitinib
Database Links Click here for help
CAS Registry No. 2222730-78-9 (source: WHO INN record)
GtoPdb PubChem SID 485205986
PubChem CID 139415233
Search Google for chemical match using the InChIKey PCKYITPVOLEZKL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PCKYITPVOLEZKL
UniChem Compound Search for chemical match using the InChIKey PCKYITPVOLEZKL-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey PCKYITPVOLEZKL-UHFFFAOYSA-N