Synonyms: JNT517
Compound class:
Synthetic organic
Comment: JNT-517 (Jnana Therapeutics) is an oral, allosteric inhibitor of SCL6A19-mediated phenylalanine reabsorption in the kidney. It is in clinical development for potential to treat phenylketonuria, an inherited metabolic disorder caused by phenylalanine hydroxylase (PAH) deficiency. The chemical structure shown here was revealed during the First Time Disclosures session at the ACS meeting in September 2023, and we picked it up from Drug Hunter. Jnana Therapeutics have a patent that claims small molecule SCL6A19 inhibitors (WO2023122267A2), but this structure doesn't appear in that patent [1].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(3R)-3-[1-cyclopropyl({[2-fluoro-4-(trifluoromethoxy)phenyl]methyl}carbamoyl)amino]piperidine-1-carboxamide |
Synonyms |
JNT517 |
Database Links | |
GtoPdb PubChem SID | 485206020 |
PubChem CID | 168510630 |
Search Google for chemical match using the InChIKey | FNRHWODWSBDOOY-CYBMUJFWSA-N |
Search Google for chemicals with the same backbone | FNRHWODWSBDOOY |
UniChem Compound Search for chemical match using the InChIKey | FNRHWODWSBDOOY-CYBMUJFWSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | FNRHWODWSBDOOY-CYBMUJFWSA-N |